Numerous compounds with a benzothiazole scaffold that have been described
in the literature show promising activities against several Gram-positive and Gramnegative
bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial
compounds bind to different biological targets in bacterial cells and have been
shown to be inhibitors of enzymes that are important for essential processes in the bacterial
cells, such as cell-wall synthesis, cell division, and DNA replication, or are important
for different biosynthetic pathways of essential compounds in bacterial cells, such as the
biosynthesis of histidine and biotin. This review focuses on the antibacterial potential of
benzothiazole-based compounds, in terms of their specific interactions with targets in
bacterial cells. We assess the importance of the benzothiazole scaffold in the discovery of
new antibacterial compounds, the potential of benzothiazole-based compounds against resistant
bacterial strains, optimization of their antibacterial activity, and the future perspectives
of benzothiazole-based antibacterials.
Keywords: Benzothiazole, antibacterial, antimycobacterial, bacterial resistance, molecular target, antibiofilm.
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