Background: Silver nanoparticles (AgNPs), are amongst the utmost striking nanosized
materials that are extensively applied in a variety of biomedical applications which
includes diagnostic use, disease management, medical device coating, drug delivery and for
personal health care.
Discussion: With the growing interest and its application in the health care sector, it is becoming
necessary for a better understanding and exploration of AgNPs mechanism of action
like biological interaction, their possible toxicity, and safety concern to human exposure.
AgNPs have been the subject of researchers attention and interest due to the unique
properties and quality such as shape and size depending optical, electrical, and antimicrobial
potentials (antibacterial, antifungal, antiviral etc.). In recent times, several studies have
been conducted on AgNPs antimicrobial potential and also a number of patents related to its
synthesis, clinical role and importance have also been registered. In this review, a short
overview of AgNPs synthesis approach is presented (physical, chemical, and biological or
green synthesis) and it also delivers a historical outlook of AgNPs application as an antimicrobial
agent which includes combined evidence of microbial resistance and safety issues
with human exposure.