Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics
Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.
Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment
that is easy to scale up.
Results: However, there are two technical issues of concern related to this method. First, the two solvents used for
this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent.
Second, the particle growth needs to be adjusted by surfactant addition.
Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble
drugs will be discussed.