Gastrin - A Potential Predictor of Response to Incretin Therapy in Diabetes Type 2 Patients

Author(s): Ines Bilic-Curcic , Maja C. Berkovic* .

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 17 , Issue 4 , 2017

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Graphical Abstract:


Background and Objectives: Personalized management of diabetes has become an imperative since majority of monotherapy fails within 3 years of its use. Identifying responders from nonresponders for a certain type of therapy would reduce a period of unsuccessful treatment and minimize health care costs. Incretin therapies, mainly glucagon-like peptide (GLP)-1 receptor agonists (GLP- 1RA) are relatively new glucose-lowering agents which increase insulin and lower glucagon response as well as slow down glucose absorption by acting on gastric emptying. However, problem with incretin- based therapy is distinguishing responders from non-responders and currently lack of specific predictors of treatment response.

Discussion: Experimental data demonstrated that activation of GLP-1 and gastrin signaling induces beta cell neogenesis, leading to glucose-dependent insulin secretion. Several studies demonstrated better glycemic control in patients with type 2 diabetes (DMT2) co-treated with proton pump inhibitors (PPI) and incretin based therapy agents.

Conclusion: Higher gastrin levels in patients with diabetes prior to initiation of treatment with incretin mimetics could suggest a better potential for reversible human β-cell reprogramming with concomitant incretin therapy. Therefore, baseline levels of endogenous gastrin could be used as a predictor of response to GLP-1 therapy. In addition, treatment with PPI could also raise gastrin levels and in patients treated with GLP-1RA, lead to better glycemic control by initiating β-cell neogenesis and proliferation of pancreatic β-cells.

Keywords: Diabetes mellitus, personalized treatment, GLP-1RA, gastrin, β-cell preservation, incretin therapy.

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Article Details

Year: 2017
Page: [297 - 302]
Pages: 6
DOI: 10.2174/1871530317666171003162104
Price: $58

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