In vitro Effects of Polyphenols on the Peripheral Immune Responses in Nickel-sensitized Patients

Author(s): Thea Magrone*, Paolo Romita, Pietro Verni, Rosaria Salvatore, Anna Spagnoletta, Manrico Magrone, Matteo A. Russo, Emilio Jirillo, Caterina Foti.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 17 , Issue 4 , 2017

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Graphical Abstract:


Background: Nickel (Ni) is a metal largely present in the environment and prolonged exposure to it may lead to multiple pathological conditions in human subjects. Among these, the most frequent is allergic contact dermatitis.

Methods: Peripheral blood mononuclear cells isolated from 25 patients with Ni-dependent contact dermatitis were evaluated in terms of cytokine release and nitric oxide (NO) production in the presence or absence of two doses (3 and 5 µg, respectively) of polyphenols.

Results: Polyphenols were able to reduce the increased release of interferon-γ and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17. At the same time, exaggerated release of NO was reduced by polyphenol supplementation.

Conclusion: In view of their anti-inflammatory activities, polyphenols may represent a potential therapeutic tool to treat Ni-sensitized patients.

Keywords: Allergic contact dermatitis, interleukin, nickel, nitric oxide, peripheral blood mononuclear cells, polyphenols.

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Article Details

Year: 2017
Page: [324 - 331]
Pages: 8
DOI: 10.2174/1871530317666171003161314
Price: $58

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PDF: 17