Background: Nickel (Ni) is a metal largely present in the environment and prolonged exposure
to it may lead to multiple pathological conditions in human subjects. Among these, the most frequent
is allergic contact dermatitis.
Methods: Peripheral blood mononuclear cells isolated from 25 patients with Ni-dependent contact
dermatitis were evaluated in terms of cytokine release and nitric oxide (NO) production in the presence
or absence of two doses (3 and 5 µg, respectively) of polyphenols.
Results: Polyphenols were able to reduce the increased release of interferon-γ and interleukin (IL)-4,
while maintaining the equilibrium between IL-10 and IL-17. At the same time, exaggerated release of
NO was reduced by polyphenol supplementation.
Conclusion: In view of their anti-inflammatory activities, polyphenols may represent a potential therapeutic
tool to treat Ni-sensitized patients.