Background: Familial Mediterranean Fever (FMF) is one of the most common hereditary
auto-inflammatory diseases especially among Arabs, Armenians, Jews, and Turks characterized by
recurrent attacks of fever, abdominal pain and arthritis.Whether the prevalence of ankylosing spondylitis
(AS) is increased in FMF patients is a matter of debate. This review will summarize all the literature
data relevant to this topic.
Methods: We searched all the articles through PubMed and Embase databases from 1963 until 2017
addressing the relationship between AS and FMF patients.
Results: The prevalence of AS among FMF patients is highly variable. However, a significant relationship
was found to exist between MEFV gene mutations and AS. Most patients with coexistent MEFV
gene mutations and AS were human leucocyte antigen B27 (HLA-B27) negative. The effect of these
mutations on AS severity and prognosis was not significant.
Conclusion: Large based population studies are needed to further assess the existence of MEFV gene
mutations among AS patients and their effect on the clinical course of the disease in addition to assessment
of AS prevalence in patients with FMF.