In Vivo and In Vitro Experiments for the Evaluation of Porous Biomaterials
Pp. 216-243 (28)
Rabia Cakir-Koc, Yasemin Budama-Kilinc, Burak Ozdemir, Zeynep Kaya, Mehtap Sert and Neslinur Ozcelik
Biomaterials used for medical application may cause some biological
responses when applied to the body. Hence, biomaterials must be tested by various in
vivo and in vitro test systems, before using on humans, according to different
standardizations like ISO 19033. These tests are made to determine the
biocompatibility of biomaterials and indicate their potential toxicity, irritation, and
non-hemocompatibility. Furthermore, biomaterials must have similar mechanical
properties as natural tissue has. For this reason, biomaterials are investigated in terms
of mechanical properties such as tensile strength, elasticity and plastic deformation,
viscoelasticity, failure, fracture, fatigue, and wear. This chapter seeks to elucidate
certain principles and procedures of in vivo and in vitro test methods that determine
biocompatibility and mechanical properties of biomaterials.
Animal studies, Biocompatibility, Biomaterials toxicity, Cell culture,
Hemocompatibility, In vivo, In vitro, Mechanical tests.
Faculty of Chemistry and Metallurgical, Department of Bioengineering, Yildiz Technical University, Davutpasa St. No.127, 34210 Esenler, Istanbul, Turkey.