Flavonoids are major dietary constituents of plant-based food found ubiquitously
in plant kingdom where they are usually present in substantial amounts. Rutin is a
flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide
rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and
antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental,
neurological, and behavioural disorders are an important and growing cause of morbidity.
Most of these disorders combine a high prevalence, early onset, progressive clinical
course, and impairment of critical brain functions making them a major contributor to
the global disease burden. In the present work, the biological in vitro and in vivo effects
and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed,
as well as their bioavailability and pharmacokinetics, which are essential for a
better understanding of its biological effectiveness. Moreover, the present review also
provides an overview of the molecular mechanisms through which rutin is proposed to
exert its neuroprotective effects.
Keywords: Alzheimer`s disease, antioxidant, flavonoid, neurodegenerative diseases, polyphenols, rutin.
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