Rutin as Neuroprotective Agent: From Bench to Bedside

Author(s): Barbara Budzynska , Caterina Faggio , Marta Kruk-Slomka , Dunja Samec , Seyed Fazel Nabavi , Antoni Sureda , Kasi Pandima Devi , Seyed Mohammad Nabavi* .

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 27 , 2019

Abstract:

Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects.

Keywords: Alzheimer`s disease, antioxidant, flavonoid, neurodegenerative diseases, polyphenols, rutin.

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Article Details

VOLUME: 26
ISSUE: 27
Year: 2019
Page: [5152 - 5164]
Pages: 13
DOI: 10.2174/0929867324666171003114154
Price: $95

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