Aptamer Oligonucleotides as Potential Therapeutics in Hematologic Diseases

Author(s): Weibin Li, Meng Zhao, Kaiyu Wang, Huihui Yan, XIaopeng lan*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 10 , 2019

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Abstract:

Background & Objective: Aptamers are single-stranded DNA or RNA oligonucleotides generated by a novel in vitro selection technique termed Systematic evolution of ligands by exponential enrichment (SELEX). During the past two decades, various aptamer drugs have been developed and many of them have entered into clinical trials.

Conclusion: In the present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia of chronic inflammation (ACI) and anemia of chronic disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) or VWD type-2B, and sickle cell disease (SCD), in particular, those that have entered into clinical trials.

Keywords: Aptamer, anemia, hemophilia, thrombotic thrombocytopenic purpura, VWD type-2B, sickle cell disease.

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Article Details

VOLUME: 19
ISSUE: 10
Year: 2019
Page: [788 - 795]
Pages: 8
DOI: 10.2174/1389557517666171002160526
Price: $95

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