Background: Fluorescent compounds had gained strong attention due to their wide and
appealing applications. Microscopic techniques and visualization are good examples among others.
Introduction of fluorescent dyes into microbiology opens the possibility to observe tissues, organisms
or organelle with exceptional sensitivity and resolution. Probes for detection of biologically
relevant metals as zinc, iron or copper seems to be particularly important for drug design and
Objective: Quinoline derivatives are well known for their good metal affinity and wide spectrum
of biological activity. In this regard, molecular sensors built on this scaffold may be useful not
only as analytical but also as therapeutic agents.
Methods: In the present review, application of quinoline moiety in designing of novel fluorescent
probes for zinc is presented and discussed.
Results: Zinc cations are relevant for vast majority of processes and recently attract a great deal of
attention for their role in neurodegenerative diseases. Compounds interacting with Zn2+ may be
used for early diagnosis of such disorders, for example the Alzheimer disease.
Conclusion: Quinoline-based zinc probes may exert some beneficial role in organism acting as
theranostic agents. First preliminary drugs for Alzheimer therapy that are based on quinoline moiety
are good example of this trend.