Regenerative Medicine Applications in Wound Care

Title:Regenerative Medicine Applications in Wound Care

Volume: 12 Issue: 8

Author(s): Mohammad Ali Nilforoushzadeh, Mahsa Mollapour Sisakht*, Alexander Marcus Seifalian, Mohammad Amir Amirkhani, Hamid Reza Banafshe, Javad Verdi, Farzaneh Sharifzad and Ehsan Taghiabadi

Affiliation:

• Applied Cell Science Department, Kashan University of Medical Sciences and Skin and Stem Cell Research Center, Tehran University of Medical Sciences, P.O. Box: 13145- 784, Tehran,Iran

Keywords: Regenerative medicine, cell therapy, wound, dermatology, skin, skin stem cell.

Abstract: Background: During the last two decades, a number of studies have been carried out on the application of regenerative medicine in the field of dermatology.

Objective: The aim of this research was to critically review the application of regenerative medicine in the field of dermatology. The next aim was to look in depth to see whether regenerative medicine strategies have a place in the future of wound healing in a clinical setting. More specifically, to see if these strategies would apply for burns and non-healing diabetic wounds.

Results: Billions of dollars have been spent worldwide on research in wound treatment and skin regeneration. Although a high number of clinical trials show promising results, there is still no commercially available treatment for use. In addition, the outcome data from the clinical trials, taking place throughout the world, are not published in a standardized manner. Standardization within clinical trials is required for: protocols, outcome, endpoint values, and length of follow-up. The lack of standardization makes it much more difficult to compare the data collected and the different types of treatment.

Conclusion: Despite several promising results from research and early phase clinical studies, the treatment for wounds as well as skin regeneration is still considered as an unmet clinical need. However, in the past three years, more promising research has been approaching clinical trials; this could be the solution that clinicians have been waiting for. This is a multibillion dollar industry for which there should be enough incentive for researchers and industry to seek the solution.

Cite this article as:

Nilforoushzadeh Ali Mohammad , Sisakht Mollapour Mahsa *, Seifalian Marcus Alexander , Amirkhani Amir Mohammad , Banafshe Reza Hamid, Verdi Javad , Sharifzad Farzaneh and Taghiabadi Ehsan , Regenerative Medicine Applications in Wound Care, Current Stem Cell Research & Therapy 2017; 12 (8) . https://dx.doi.org/10.2174/1574888X12666170929123842