Objectives: The purpose of the study was to investigate the effect of the aqueous extract of
Anabasis aretioides (A. aretioides) on blood glucose levels and lipid metabolism in normal and streptozotocin-
induced diabetic rat.
Methods: The effect of A. aretioides aerial part aqueous extract (A.P.A.E) (5 mg/kg) on blood glucose
levels was investigated in normal and streptozotocin (STZ) diabetic rats (n=6). A preliminary
screening for various bioactive constituents was realized and the antioxidant potential of the aqueous
extract was also demonstrated. The histopathological changes in liver and pancreas have been evaluated
both in normal and STZ diabetic rats.
Key Findings: Both single and oral administration of the A.P.A.E (5 mg/kg) caused a significant reduction
on blood glucose levels in STZ rats (p<0.0001). Moreover, the preliminary phytochemical
screening of A. aretioides A.P.A.E has demonstrated the presence of polyphenols, tannins, saponins,
mucilage, sterol, sesquiterpenes, terpenoids, carbohydrates and glycosides.
Conclusion: We conclude that A. aretioides aqueous extract exhibits antihyperglycemic activity.