A Green Ultrasound Synthesis, Characterization and their Antibacterial Evaluation of Novel Transition Metal Complex of 2-amino-5-Aryl-1, 3, 4- THIADIAZOLE

Author(s): Satinder Kanwar, Dinesh K. Mehta*, Rina Das, Girish K. Gupta.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 7 , 2018

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Graphical Abstract:


In the present study a series of metal complex of [bis (2-amino-5-aryl-1,3,4-thiadiazole]2Cl (S1-S9) was synthesized by using ultrasound irradiation technique. The metal complex was synthesized by the reaction between ligand and appropriate metal salts (CuCl2. 2H2O, CoCl2. 6H2O, ZnCl2, MgCl2. 4H2O, NiCl2. 6H2O). The products were obtained in high yield and the reaction time was found to be shorter. The synthesized metal complexes were characterized by using UV-visible spectroscopy, FTIR, 1H NMR and Mass spectroscopy. The synthesized compounds were investigated for antibacterial potential against gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) and gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli). Significant activity was observed for synthesized metal complexes S6 and S7 against B. subtilis and S. aureus.

Keywords: Antibacterial activity, green chemistry, 1, 3, 4-thiadiazole, sonochemistry, regional, metal salt.

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Article Details

Year: 2018
Page: [633 - 639]
Pages: 7
DOI: 10.2174/1570178614666170927162125
Price: $65

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