The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review

Author(s): Jaya Dwivedi*, Swapnil Sharma, Sonika Jain, Aarti Singh.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 11 , 2018

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Abstract:

Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.

Keywords: Combinatorial chemistry, medicinal chemistry, pharmacological activity, pharmacophore, pyrazole, QSAR.

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Article Details

VOLUME: 18
ISSUE: 11
Year: 2018
Page: [918 - 947]
Pages: 30
DOI: 10.2174/1389557517666170927160919
Price: $58

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