1,3,5-Triazine-based compounds form a privileged class of compounds in the medicinal
chemistry field as they are versatile synthetic scaffolds possessing wide spectra of biological effects
including potential anticancer activity. 1,3,5-Triazine compounds explored for anticancer activities
have been reported to act by various mechanisms on several molecular targets in human cells such as
methyltransferase (DNMT), heat shock protein 90 (Hsp90) and phosphoinositide 3-kinase (PI3K). This
review focuses on the synthetic strategies for current developments of 1,3,5-triazine-based anticancer
agents and discuses the docking studies that confirm their unique binding modes in the targeted receptors
active sites. This article also aims to highlight the future directions for the easy access to these
frameworks of more potent and specific anticancer activity.
Keywords: Anticancer, enzymes, molecular docking, synthetic methods, 1, 3, 5-triazines, anti-protozoals.
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