Herbs for Effective Treatment of Diabetes Mellitus Wounds: Medicinal Chemistry and Future Therapeutic Options

Author(s): Farida Hussan, Mohamad Fairuz Yahaya, Seong Lin Teoh, Srijit Das*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 8 , 2018

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Graphical Abstract:


The incidence of diabetes mellitus (DM) has increased globally. Various complications such as blindness, nephropathy leading to renal failure, neuropathy, foot ulceration, amputation, and disturbance in autonomic nervous system were reported. Although, allopathy treatment still remains the treatment of choice, there is a need to look at the easy availability, patient compliance and cheaper cost of the drugs used in day-day practice. In this regard, complementary and alternative medicine has a greater role to play. Numerous plant extracts were shown to exhibit antihyperglycemic properties. In the present review, we surfed published literature in Pubmed and google databases with regard to the herbs used for DM wound treatment. We also discuss the possible mechanism of wound healing in DM with regard to advanced glycation end products, inflammation, macrophages, non-leukocytic cells such as keratinocytes, fibroblasts and endothelial cells, matrix metalloproteinase and miRNA. The review opens the door for effective treatment of DM wounds with plant extracts and plan future treatment options.

Keywords: Angiogenesis, diabetes mellitus, wound, healing, herb, macrophage, insulin.

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Article Details

Year: 2018
Page: [697 - 710]
Pages: 14
DOI: 10.2174/1389557517666170927155707
Price: $58

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