Background: Bone tissue engineering is an important research area that uses biomaterials
as support matrices for the growth of living tissues. Biomaterials provide the basis for growing tissue,
allowing the repair and regeneration of natural tissue. In recent years, the preparation of scaffolds
useful for bone tissue engineering has been increasingly studied, mainly due to the great capacity of
these structures to restore or regenerate tissues quickly.
Objective: This literature review aims to prove the linear growing use of the main conventional
methodologies used to produce scaffolds for bone tissue engineering. In addition, the conventional
preparation methods, such as the formation of gas foams, emulsification, electro-spinning, leaching
and phase separation are presented.
Method: The study was based on a bibliometric research, where more than four hundred papers were
141.160 papers were classified using the CAPES - Portal of Periodicals (CAPES-PP). More
specifically, the keyword “scaffold” was used alone and in association with each of the conventional
techniques here presented.
Results: As proved here, conventional
methods undergo an increasing relative importance, showing an
increasing rate during the studied years equivalent to 0.70±0.05 works/year (R2 = 0.92). In 2016,
conventional techniques accounted for more than one-quarter of the publications about the subject.
Conclusion: The obtained results allow concluding that the scientific community is looking for
reliable, cheap and efficient ways to produce this kind of technology on a larger scale and the
conventional techniques are the most solid pathway to spread up this technology.