Organic Nanotheranostics for Photoacoustic Imaging-Guided Phototherapy

Author(s): Houjuan Zhu, Chen Xie, Peng Chen, Kanyi Pu*.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 8 , 2019

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Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have emerged as one of the avant-garde strategies for cancer treatment. Photoacoustic (PA) imaging is a new hybrid imaging modality that shows great promise for real-time in vivo monitoring of biological processes with deep tissue penetration and high spatial resolution. To enhance therapeutic efficacy, reduce side effects and minimize the probability of over-medication, it is necessary to use imaging and diagnostic methods to identify the ideal therapeutic window and track the therapeutic outcome. With this regard, nanotheranostics with the ability to conduct PA imaging and PTT/PDT are emerging. This review summarizes the recent progress of organic nanomaterials including nearinfrared (NIR) dyes and semiconducting polymer nanoparticles (SPNs) in PA imaging guided cancer phototherapy, and also addresses their present challenges and potential in clinical applications.

Keywords: Photothermal therapy, Photodynamic therapy, Photoacoustic imaging, Nanotheranostic, Near infrared dyes, Semiconducting polymers.

Celli, J.P.; Spring, B.Q.; Rizvi, I.; Evans, C.L.; Samkoe, K.S.; Verma, S.; Pogue, B.W.; Hasan, T. Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. Chem. Rev., 2010, 110(5), 2795-2838.
Lal, S.; Clare, S.E.; Halas, N.J. Nanoshell-enabled photothermal cancer therapy: impending clinical impact. Acc. Chem. Res., 2008, 41(12), 1842-1851.
Cheng, L.; Wang, C.; Feng, L.; Yang, K.; Liu, Z. Functional nanomaterials for phototherapies of cancer. Chem. Rev., 2014, 114(21), 10869-10939.
Liu, H.; Chen, D.; Li, L.; Liu, T.; Tan, L.; Wu, X.; Tang, F. Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. Angew. Chem. Int. Ed. Engl., 2011, 50(4), 891-895.
Dong, W.; Li, Y.; Niu, D.; Ma, Z.; Gu, J.; Chen, Y.; Zhao, W.; Liu, X.; Liu, C.; Shi, J. Facile synthesis of monodisperse superparamagnetic Fe3O4 Core@hybrid@Au shell nanocomposite for bimodal imaging and photothermal therapy. Adv. Mater., 2011, 23(45), 5392-5397.
Zhang, Z.; Wang, L.; Wang, J.; Jiang, X.; Li, X.; Hu, Z.; Ji, Y.; Wu, X.; Chen, C. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv. Mater., 2012, 24(11), 1418-1423.
Liu, X.; Sun, H.; Yan, D.; Zhang, L.; Lv, X.; Liu, T.; Zhang, W.; Liu, W.; Cao, Y.; Zhou, G. In vivo ectopic chondrogenesis of BMSCs directed by mature chondrocytes. Biomaterials, 2010, 31(36), 9406-9414.
Yang, W.; Bai, T.; Carr, L.R.; Keefe, A.J.; Xu, J.; Xue, H.; Irvin, C.A.; Chen, S.; Wang, J.; Jiang, S. The effect of lightly crosslinked poly(carboxybetaine) hydrogel coating on the performance of sensors in whole blood. Biomaterials, 2012, 33(32), 7945-7951.
Yang, K.; Zhang, S.; Zhang, G.; Sun, X.; Lee, S.T.; Liu, Z. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett., 2010, 10(9), 3318-3323.
Robinson, J.T.; Tabakman, S.M.; Liang, Y.; Wang, H.; Casalongue, H.S.; Vinh, D.; Dai, H. Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J. Am. Chem. Soc., 2011, 133(17), 6825-6831.
Tian, B.; Wang, C.; Zhang, S.; Feng, L.; Liu, Z. Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. ACS Nano, 2011, 5(9), 7000-7009.
Yang, K.; Hu, L.; Ma, X.; Ye, S.; Cheng, L.; Shi, X.; Li, C.; Li, Y.; Liu, Z. Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Adv. Mater., 2012, 24(14), 1868-1872.
Cheng, L.; Yang, K.; Li, Y.; Chen, J.; Wang, C.; Shao, M.; Lee, S.T.; Liu, Z. Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. Angew. Chem. Int. Ed. Engl., 2011, 50(32), 7385-7390.
Xing, C.; Xu, Q.; Tang, H.; Liu, L.; Wang, S. Conjugated polymer/porphyrin complexes for efficient energy transfer and improving light-activated antibacterial activity. J. Am. Chem. Soc., 2009, 131(36), 13117-13124.
Manyak, M.J.; Ogan, K. Photodynamic therapy for refractory superficial bladder cancer: long-term clinical outcomes of single treatment using intravesical diffusion medium. J. Endourol., 2003, 17(8), 633-639.
Liu, K.; Liu, X.; Zeng, Q.; Zhang, Y.; Tu, L.; Liu, T.; Kong, X.; Wang, Y.; Cao, F.; Lambrechts, S.A.G.; Aalders, M.C.G.; Zhang, H. Covalently assembled NIR nanoplatform for simultaneous fluorescence imaging and photodynamic therapy of cancer cells. ACS Nano, 2012, 6(5), 4054-4062.
Brown, S.B.; Brown, E.A.; Walker, I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol., 2004, 5(8), 497-508.
Zhang, P.; Steelant, W.; Kumar, M.; Scholfield, M. Versatile photosensitizers for photodynamic therapy at infrared excitation. J. Am. Chem. Soc., 2007, 129(15), 4526-4527.
Dolmans, D.E.J.G.J.; Fukumura, D.; Jain, R.K. Photodynamic therapy for cancer. Nat. Rev. Cancer, 2003, 3(5), 380-387.
Huang, P.; Lin, J.; Wang, X.; Wang, Z.; Zhang, C.; He, M.; Wang, K.; Chen, F.; Li, Z.; Shen, G.; Cui, D.; Chen, X. Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy. Adv. Mater., 2012, 24(37), 5104-5110.
Wang, S.; Huang, P.; Nie, L.; Xing, R.; Liu, D.; Wang, Z.; Lin, J.; Chen, S.; Niu, G.; Lu, G.; Chen, X. Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars. Adv. Mater., 2013, 25(22), 3055-3061.
Terentyuk, G.; Panfilova, E.; Khanadeev, V.; Chumakov, D.; Genina, E.; Bashkatov, A.; Tuchin, V.; Bucharskaya, A.; Maslyakova, G.; Khlebtsov, N.; Khlebtsov, B. Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo. Nano Res., 2014, 7(3), 325-337.
Huang, P.; Pandoli, O.; Wang, X.S.; Wang, Z.; Li, Z.M.; Zhang, C.L.; Chen, F.; Lin, J.; Cui, D.X.; Chen, X.Y. Chiral guanosine 5′-monophosphate-capped gold nanoflowers: controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy. Nano Res., 2012, 5(9), 630-639.
Cheng, Y.; Samia, A.C.; Meyers, J.D.; Panagopoulos, I.; Fei, B.; Burda, C. Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. J. Am. Chem. Soc., 2008, 130(32), 10643-10647.
Kuo, W.S.; Chang, C.N.; Chang, Y.T.; Yang, M.H.; Chien, Y.H.; Chen, S.J.; Yeh, C.S. Gold nanorods in photodynamic therapy, as hyperthermia agents, and in near-infrared optical imaging. Angew. Chem. Int. Ed. Engl., 2010, 49(15), 2711-2715.
Boca, S.C.; Potara, M.; Gabudean, A.M.; Juhem, A.; Baldeck, P.L.; Astilean, S. Chitosan-coated triangular silver nanoparticles as a novel class of biocompatible, highly effective photothermal transducers for in vitro cancer cell therapy. Cancer Lett., 2011, 311(2), 131-140.
Hu, B.; Wang, N.; Han, L.; Chen, M.L.; Wang, J.H. Core-shell-shell nanorods for controlled release of silver that can serve as a nanoheater for photothermal treatment on bacteria. Acta Biomater., 2015, 11, 511-519.
Di Corato, R.; Palumberi, D.; Marotta, R.; Scotto, M.; Carregal-Romero, S.; Rivera Gil, P.; Parak, W.J.; Pellegrino, T. Magnetic nanobeads decorated with silver nanoparticles as cytotoxic agents and photothermal probes. Small, 2012, 8(17), 2731-2742.
Manikandan, M.; Hasan, N.; Wu, H.F. Platinum nanoparticles for the photothermal treatment of Neuro 2A cancer cells. Biomaterials, 2013, 34(23), 5833-5842.
Wang, C.; Cai, X.; Zhang, J.; Wang, X.; Wang, Y.; Ge, H.; Yan, W.; Huang, Q.; Xiao, J.; Zhang, Q.; Cheng, Y. Trifolium-like platinum nanoparticle-mediated photothermal therapy inhibits tumor growth and osteolysis in a bone metastasis model. Small, 2015, 11(17), 2080-2086.
Chen, D.H.; Gao, S.P.; Ge, W.; Li, Q.W.; Jiang, H.; Wang, X.M. One-step rapid synthesis of fluorescent platinum nanoclusters for cellular imaging and photothermal treatment. RSC Advances, 2014, 4(76), 40141-40145.
Obata, M.; Hirohara, S.; Tanaka, R.; Kinoshita, I.; Ohkubo, K.; Fukuzumi, S.; Tanihara, M.; Yano, S. In vitro heavy-atom effect of palladium(II) and platinum(II) complexes of pyrrolidine-fused chlorin in photodynamic therapy. J. Med. Chem., 2009, 52(9), 2747-2753.
Yi, X.; Yang, K.; Liang, C.; Zhong, X.Y.; Ning, P.; Song, G.S.; Wang, D.L.; Ge, C.C.; Chen, C.Y.; Chai, Z.F.; Liu, Z. Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles. Adv. Funct. Mater., 2015, 25(29), 4689-4699.
Bu, X.; Zhou, D.; Li, J.; Zhang, X.; Zhang, K.; Zhang, H.; Yang, B. Copper sulfide self-assembly architectures with improved photothermal performance. Langmuir, 2014, 30(5), 1416-1423.
Wang, S.; Li, X.; Chen, Y.; Cai, X.; Yao, H.; Gao, W.; Zheng, Y.; An, X.; Shi, J.; Chen, H. A facile one-pot synthesis of a two-dimensional MoS2/Bi2S3 composite theranostic nanosystem for multi-modality tumor imaging and therapy. Adv. Mater., 2015, 27(17), 2775-2782.
Liu, J.; Zheng, X.; Yan, L.; Zhou, L.; Tian, G.; Yin, W.; Wang, L.; Liu, Y.; Hu, Z.; Gu, Z.; Chen, C.; Zhao, Y. Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor. ACS Nano, 2015, 9(1), 696-707.
Zhou, M.; Song, S.L.; Li, C. Theranostic CuS nanoparticles targeting folate receptors for PET/CT image-guided photothermal ablation therapy. J. Mater. Chem. B Mater. Biol. Med., 2015, 3(46), 8939-8948.
Yong, Y.; Cheng, X.; Bao, T.; Zu, M.; Yan, L.; Yin, W.; Ge, C.; Wang, D.; Gu, Z.; Zhao, Y. Tungsten sulfide quantum dots as multifunctional nanotheranostics for in vivo dual-modal image-guided photothermal/radiotherapy synergistic therapy. ACS Nano, 2015, 9(12), 12451-12463.
Chen, Z.; Yin, G. The reactivity of the active metal oxo and hydroxo intermediates and their implications in oxidations. Chem. Soc. Rev., 2015, 44(5), 1083-1100.
Liu, T.; Wang, C.; Gu, X.; Gong, H.; Cheng, L.; Shi, X.; Feng, L.; Sun, B.; Liu, Z. Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer. Adv. Mater., 2014, 26(21), 3433-3440.
Song, G.; Liang, C.; Gong, H.; Li, M.; Zheng, X.; Cheng, L.; Yang, K.; Jiang, X.; Liu, Z. Core-shell MnSe@Bi2Se3 fabricated via a cation exchange method as novel nanotheranostics for multimodal imaging and synergistic thermoradiotherapy. Adv. Mater., 2015, 27(40), 6110-6117.
Zhu, H.; Lai, Z.; Fang, Y.; Zhen, X.; Tan, C.; Qi, X.; Ding, D.; Chen, P.; Zhang, H.; Pu, K. Ternary chalcogenide nanosheets with ultrahigh photothermal conversion efficiency for photoacoustic theranostics. Small, 2017, 13(16), 1604139.
Cheng, L.; Liu, J.; Gu, X.; Gong, H.; Shi, X.; Liu, T.; Wang, C.; Wang, X.; Liu, G.; Xing, H.; Bu, W.; Sun, B.; Liu, Z. PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv. Mater., 2014, 26(12), 1886-1893.
Liu, Z.; Liu, J.; Wang, R.; Du, Y.; Ren, J.; Qu, X. An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract. Biomaterials, 2015, 56, 206-218.
Tian, G.; Zhang, X.; Zheng, X.; Yin, W.; Ruan, L.; Liu, X.; Zhou, L.; Yan, L.; Li, S.; Gu, Z.; Zhao, Y. Multifunctional Rbx WO3 nanorods for simultaneous combined chemo-photothermal therapy and photoacoustic/CT imaging. Small, 2014, 10(20), 4160-4170.
Lin, L.S.; Cong, Z.X.; Cao, J.B.; Ke, K.M.; Peng, Q.L.; Gao, J.; Yang, H.H.; Liu, G.; Chen, X. Multifunctional Fe3O4@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy. ACS Nano, 2014, 8(4), 3876-3883.
Chen, Q.; Feng, L.; Liu, J.; Zhu, W.; Dong, Z.; Wu, Y.; Liu, Z. Intelligent albumin-MnO2 nanoparticles as pH-/H2O2-responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy. Adv. Mater., 2016, 28(33), 7129-7136.
Song, G.; Hao, J.; Liang, C.; Liu, T.; Gao, M.; Cheng, L.; Hu, J.; Liu, Z. Degradable molybdenum oxide nanosheets with rapid clearance and efficient tumor homing capabilities as a therapeutic nanoplatform. Angew. Chem. Int. Ed. Engl., 2016, 55(6), 2122-2126.
Jin, Y.; Li, Y.; Ma, X.; Zha, Z.; Shi, L.; Tian, J.; Dai, Z. Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer. Biomaterials, 2014, 35(22), 5795-5804.
Su, S.H.; Wang, J.L.; Wei, J.H.; Martinez-Zaguilan, R.; Qiu, J.J.; Wang, S.R. Efficient photothermal therapy of brain cancer through porphyrin functionalized graphene oxide. New J. Chem., 2015, 39(7), 5743-5749.
Wang, J.L.; Qiu, J.J. Luminescent graphene quantum dots: as emerging fluorescent materials for biological application. Sci. Adv. Mater., 2015, 7(10), 1979-1989.
Wang, J.L.; Wei, J.H.; Su, S.H.; Qiu, J.J. Novel fluorescence resonance energy transfer optical sensors for vitamin B-12 detection using thermally reduced carbon dots. New J. Chem., 2015, 39(1), 501-507.
Wang, J.L.; Su, S.H.; Wei, J.H.; Bahgi, R.; Hope-Weeks, L.; Qiu, J.J.; Wang, S.R. Ratio-metric sensor to detect riboflavin via fluorescence resonance energy transfer with ultrahigh sensitivity. Physica E Low Dimens. Syst. Nanostruct, 2015, 72, 17-24.
Gopi, D.; Shinyjoy, E.; Kavitha, L. Influence of ionic substitution in improving the biological property of carbon nanotubes reinforced hydroxyapatite composite coating on titanium for orthopedic applications. Ceram. Int., 2015, 41(4), 5454-5463.
Mundra, R.V.; Wu, X.; Sauer, J.; Dordick, J.S.; Kane, R.S. Nanotubes in biological applications. Curr. Opin. Biotechnol., 2014, 28, 25-32.
Huang, P.; Xu, C.; Lin, J.; Wang, C.; Wang, X.; Zhang, C.; Zhou, X.; Guo, S.; Cui, D. Folic acid-conjugated graphene oxide loaded with photosensitizers for targeting photodynamic therapy. Theranostics, 2011, 1, 240-250.
Sharker, S.M.; Lee, J.E.; Kim, S.H.; Jeong, J.H. pH triggered in vivo photothermal therapy and fluorescence nanoplatform of cancer based on responsive polymer-indocyanine green integrated reduced graphene oxide. Biomaterials, 2015, 61229-61238.
Sheng, Z.H.; Hu, D.H.; Xue, M.M.; He, M.; Gong, P.; Cai, L.T. Indocyanine green nanoparticles for theranostic applications. Nano-Micro Lett., 2013, 5(3), 145-150.
Zheng, M.; Zhao, P.; Luo, Z.; Gong, P.; Zheng, C.; Zhang, P.; Yue, C.; Gao, D.; Ma, Y.; Cai, L. Robust ICG theranostic nanoparticles for folate targeted cancer imaging and highly effective photothermal therapy. ACS Appl. Mater. Interfaces, 2014, 6(9), 6709-6716.
Liu, P.; Yue, C.; Shi, B.; Gao, G.; Li, M.; Wang, B.; Ma, Y.; Cai, L. Dextran based sensitive theranostic nanoparticles for near-infrared imaging and photothermal therapy in vitro. Chem. Commun. (Camb.), 2013, 49(55), 6143-6145.
Jian, W.H.; Yu, T.W.; Chen, C.J.; Huang, W.C.; Chiu, H.C.; Chiang, W.H. Indocyanine green-encapsulated hybrid polymeric nanomicelles for photothermal cancer therapy. Langmuir, 2015, 31(22), 6202-6210.
Yan, L.; Qiu, L. Indocyanine green targeted micelles with improved stability for near-infrared image-guided photothermal tumor therapy. Nanomedicine, 2015, 10(3), 361-373.
Urbanska, K.; Romanowska-Dixon, B.; Matuszak, Z.; Oszajca, J.; Nowak-Sliwinska, P.; Stochel, G. Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas. Acta Biochim. Pol., 2002, 49(2), 387-391.
Crescenzi, E.; Varriale, L.; Iovino, M.; Chiaviello, A.; Veneziani, B.M.; Palumbo, G. Photodynamic therapy with indocyanine green complements and enhances low-dose cisplatin cytotoxicity in MCF-7 breast cancer cells. Mol. Cancer Ther., 2004, 3(5), 537-544.
Zhao, C.Q.; Rehman, F.U.; Yang, Y.L.; Li, X.Q.; Zhang, D.; Jiang, H.; Selke, M.; Wang, X.M.; Liu, C.Y. Bio-imaging and photodynamic therapy with tetra sulphonatophenyl porphyrin (TSPP)-TiO2 nanowhiskers: new approaches in rheumatoid arthritis theranostics. Sci. Rep., 2015, 5, 11518.
Lovell, J.F.; Jin, C.S.; Huynh, E.; Jin, H.; Kim, C.; Rubinstein, J.L.; Chan, W.C.W.; Cao, W.; Wang, L.V.; Zheng, G. Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nat. Mater., 2011, 10(4), 324-332.
Chen, M.; Fang, X.; Tang, S.; Zheng, N. Polypyrrole nanoparticles for high-performance in vivo near-infrared photothermal cancer therapy. Chem. Commun., 2012, 48(71), 8934-8936.
Zha, Z.B.; Wang, J.R.; Qu, E.Z.; Zhang, S.H.; Jin, Y.S.; Wang, S.M.; Dai, Z.F. Polypyrrole hollow microspheres as echogenic photothermal agent for ultrasound imaging guided tumor ablation. Sci. Rep., 2013, 3, 2360-2367.
Du, C.L.; Wang, A.H.; Fei, J.B.; Zhao, J.; Li, J.B. Polypyrrole-stabilized gold nanorods with enhanced photothermal effect towards two-photon photothermal therapy. J. Mater. Chem. B Mater. Biol. Med., 2015, 3(22), 4539-4545.
Song, X.; Liang, C.; Gong, H.; Chen, Q.; Wang, C.; Liu, Z. Photosensitizer-conjugated albumin-polypyrrole nanoparticles for imaging-guided in vivo photodynamic/photothermal therapy. Small, 2015, 11(32), 3932-3941.
Liang, X.L.; Li, Y.Y.; Li, X.D.; Jing, L.J.; Deng, Z.J.; Yue, X.L.; Li, C.H.; Dai, Z.F. PEGylated polypyrrole nanoparticles conjugating gadolinium chelates for dual-modal MRI/photoacoustic imaging guided photothermal therapy of cancer. Adv. Funct. Mater., 2015, 25(9), 1451-1462.
Lee, H.; Hong, W.; Jeon, S.; Choi, Y.; Cho, Y. Electroactive polypyrrole nanowire arrays: synergistic effect of cancer treatment by on-demand drug release and photothermal therapy. Langmuir, 2015, 31(14), 4264-4269.
Peng, Z.; Qin, J.; Li, B.; Ye, K.; Zhang, Y.; Yang, X.; Yuan, F.; Huang, L.; Hu, J.; Lu, X. An effective approach to reduce inflammation and stenosis in carotid artery: polypyrrole nanoparticle-based photothermal therapy. Nanoscale, 2015, 7(17), 7682-7691.
Wang, C.; Xu, H.; Liang, C.; Liu, Y.; Li, Z.; Yang, G.; Cheng, L.; Li, Y.; Liu, Z. Iron oxide @ polypyrrole nanoparticles as a multifunctional drug carrier for remotely controlled cancer therapy with synergistic antitumor effect. ACS Nano, 2013, 7(8), 6782-6795.
Ke, K.; Lin, L.; Liang, H.; Chen, X.; Han, C.; Li, J.; Yang, H.H. Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy. Chem. Commun., 2015, 51(31), 6800-6803.
Feng, W. Zhou, X.; Nie, W.; Chen, L.; Qiu, K.; Zhang, Y.; He, C. Au/polypyrrole@Fe3O4 nanocomposites for MR/CT dual-modal imaging guided-photothermal therapy: an in vitro study. ACS Appl. Mater. Interfaces, 2015, 7(7), 4354-4367.
Zhang, Y.; Pang, L.; Ma, C.; Tu, Q.; Zhang, R.; Saeed, E.; Mahmoud, A.E.; Wang, J. Small molecule-initiated light-activated semiconducting polymer dots: an integrated nanoplatform for targeted photodynamic therapy and imaging of cancer cells. Anal. Chem., 2014, 86(6), 3092-3099.
Samia, A.C.S.; Dayal, S.; Burda, C. Quantum dot-based energy transfer: perspectives and potential for applications in photodynamic therapy. Photochem. Photobiol., 2006, 82(3), 617-625.
Huang, Y.; He, S.; Cao, W.; Cai, K.; Liang, X.J. Biomedical nanomaterials for imaging-guided cancer therapy. Nanoscale, 2012, 4(20), 6135-6149.
Fernando, R.; Downs, J.; Maples, D.; Ranjan, A. MRI-guided monitoring of thermal dose and targeted drug delivery for cancer therapy. Pharm. Res., 2013, 30(11), 2709-2717.
Huang, G.; Zhu, X.; Li, H.; Wang, L.; Chi, X.; Chen, J.; Wang, X.; Chen, Z.; Gao, J. Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy. Nanoscale, 2015, 7(6), 2667-2675.
Yuan, Y.; Sun, H.; Ge, S.; Wang, M.; Zhao, H.; Wang, L.; An, L.; Zhang, J.; Zhang, H.; Hu, B.; Wang, J.; Liang, G. Controlled intracellular self-assembly and disassembly of 19F nanoparticles for MR imaging of caspase 3/7 in zebrafish. ACS Nano, 2015, 9(1), 761-768.
Song, X.; Gong, H.; Liu, T.; Cheng, L.; Wang, C.; Sun, X.; Liang, C.; Liu, Z. J-aggregates of organic dye molecules complexed with iron oxide nanoparticles for imaging-guided photothermal therapy under 915-nm light. Small, 2014, 10(21), 4362-4370.
Jing, L.; Liang, X.; Li, X.; Lin, L.; Yang, Y.; Yue, X.; Dai, Z. Mn-porphyrin conjugated Au nanoshells encapsulating doxorubicin for potential magnetic resonance imaging and light triggered synergistic therapy of cancer. Theranostics, 2014, 4(9), 858-871.
Zhou, J.; Wang, X.J.; Li, L.Y.; Lu, Z.G.; Li, K. Gadolinum complex-modified polypyrrole nanorods for magnetic resonance imaging and infrared thermal imaging-guided photothermal therapy of cancer. Sci. Adv. Mater., 2015, 7(9), 1708-1716.
Liang, C.; Diao, S.; Wang, C.; Gong, H.; Liu, T.; Hong, G.; Shi, X.; Dai, H.; Liu, Z. Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes. Adv. Mater., 2014, 26(32), 5646-5652.
Yang, Y.; Liu, J.; Liang, C.; Feng, L.; Fu, T.; Dong, Z.; Chao, Y.; Li, Y.; Lu, G.; Chen, M.; Liu, Z. Nanoscale metal-organic particles with rapid clearance for magnetic resonance imaging-guided photothermal therapy. ACS Nano, 2016, 10(2), 2774-2781.
Roland, F.M.; Guha, S.; Smith, B.D. Dye-doped nanoparticles for tumor imaging and photothermal therapy. J. Nucl. Med., 2015, 56(2), 16-17.
Cheng, H.; Zhu, J.Y.; Li, S.Y.; Zeng, J.Y.; Lei, Q.; Chen, K.W.; Zhang, C.; Zhang, X.Z. An O2 self-sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy. Adv. Funct. Mater., 2016, 26(43), 7847-7860.
Peng, Y.; Xiong, B.; Peng, L.; Li, H.; He, Y.; Yeung, E.S. Recent advances in optical imaging with anisotropic plasmonic nanoparticles. Anal. Chem., 2015, 87(1), 200-215.
Yuan, Y.; Liu, J.; Liu, B. Conjugated-polyelectrolyte-based polyprodrug: targeted and image-guided photodynamic and chemotherapy with on-demand drug release upon irradiation with a single light source. Angew. Chem. Int. Ed. Engl., 2014, 53(28), 7163-7168.
Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X.; Chen, H. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34(36), 9124-9133.
Yue, C.; Liu, P.; Zheng, M.; Zhao, P.; Wang, Y.; Ma, Y.; Cai, L. IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy. Biomaterials, 2013, 34(28), 6853-6861.
Han, K.; Wang, S.B.; Lei, Q.; Zhu, J.Y.; Zhang, X.Z. Ratiometric biosensor for aggregation-induced emission-guided precise photodynamic therapy. ACS Nano, 2015, 9(10), 10268-10277.
Wang, S.; Shang, L.; Li, L.; Yu, Y.; Chi, C.; Wang, K.; Zhang, J.; Shi, R.; Shen, H.; Waterhouse, G.I.N.; Liu, S.; Tian, J.; Zhang, T.; Liu, H. Metal-organic-framework-derived mesoporous carbon nanospheres containing porphyrin-like metal centers for conformal phototherapy. Adv. Mater., 2016, 28(38), 8379-8387.
Wang, H.; Sun, Y.; Yi, J.; Fu, J.; Di, J.; del Carmen Alonso, A.; Zhou, S. Fluorescent porous carbon nanocapsules for two-photon imaging, NIR/pH dual-responsive drug carrier, and photothermal therapy. Biomaterials, 2015, 53, 117-126.
Sadat, M.E.; Baghbador, M.K.; Dunn, A.W.; Wagner, H.P.; Ewing, R.C.; Zhang, J.M.; Xu, H.; Pauletti, G.M.; Mast, D.B.; Shi, D.L. Photoluminescence and photothermal effect of Fe3O4 nanoparticles for medical imaging and therapy. Appl. Phys. Lett., 2014, 105(9), 091903.
Liu, L.H.; Qiu, W.X.; Bin, L.; Zhang, C.; Sun, L.F.; Wan, S.S.; Rong, L.; Zhang, X.Z. A red light activatable multifunctional prodrug for image-guided photodynamic therapy and cascaded chemotherapy. Adv. Funct. Mater., 2016, 26(34), 6257-6269.
Lv, R.C.; Yang, P.P.; He, F.; Gai, S.L.; Yang, G.X.; Lin, J. Hollow structured Y2O3:Yb/Er-CuxS nanospheres with controllable size for simultaneous chemo/photothermal therapy and bioimaging. Chem. Mater., 2015, 27(2), 483-496.
Wang, S.; Dai, Z.; Ke, H.; Qu, E.; Qi, X.; Zhang, K.; Wang, J. Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer. Eur. J. Radiol., 2014, 83(1), 117-122.
Zha, Z.; Wang, S.; Zhang, S.; Qu, E.; Ke, H.; Wang, J.; Dai, Z. Targeted delivery of CuS nanoparticles through ultrasound image-guided microbubble destruction for efficient photothermal therapy. Nanoscale, 2013, 5(8), 3216-3219.
Zha, Z.; Wang, J.; Zhang, S.; Wang, S.; Qu, E.; Zhang, Y.; Dai, Z. Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer. Biomaterials, 2014, 35(1), 287-293.
Park, D.J.; Min, K.H.; Lee, H.J.; Kim, K.; Kwon, I.C.; Jeong, S.Y.; Lee, S.C. Photosensitizer-loaded bubble-generating mineralized nanoparticles for ultrasound imaging and photodynamic therapy. J. Mater. Chem. B Mater. Biol. Med., 2016, 4(7), 1219-1227.
Ke, H.; Wang, J.; Dai, Z.; Jin, Y.; Qu, E.; Xing, Z.; Guo, C.; Yue, X.; Liu, J. Gold-nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew. Chem. Int. Ed. Engl., 2011, 50(13), 3017-3021.
Tan, L.F.; Liu, T.L.; Fu, C.H.; Wang, S.P.; Fu, S.Y.; Ren, J.; Meng, X.W. Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy. J. Mater. Chem. B Mater. Biol. Med., 2016, 4(5), 859-866.
Wang, L.; Meng, D.; Hao, Y.; Zhao, Y.; Li, D.; Zhang, B.; Zhang, Y.; Zhang, Z. Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications. J. Biomater. Appl., 2015, 30(5), 547-557.
Tian, Y.; Luo, S.; Yan, H.J.; Teng, Z.G.; Pan, Y.W.; Zeng, L.Y.; Wu, J.; Li, Y.J.; Liu, Y.; Wang, S.J.; Lu, G.M. Gold nanostars functionalized with amine-terminated PEG for X-ray/CT imaging and photothermal therapy. J. Mater. Chem. B Mater. Biol. Med., 2015, 3(21), 4330-4337.
Sun, B.M.; Wu, J.R.; Cui, S.B.; Zhu, H.H.; An, W.; Fu, Q.G.; Shao, C.W.; Yao, A.H.; Chen, B.D.; Shi, D.L. In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy. Nano Res., 2017, 10(1), 37-48.
Park, J.; Park, J.; Ju, E.J.; Park, S.S.; Choi, J.; Lee, J.H.; Lee, K.J.; Shin, S.H.; Ko, E.J.; Park, I.; Kim, C.; Hwang, J.J.; Lee, J.S.; Song, S.Y.; Jeong, S.Y.; Choi, E.K. Multifunctional hollow gold nanoparticles designed for triple combination therapy and CT imaging. J. Control. Release, 2015, 207, 77-85.
Hao, Y.; Zhang, B.; Zheng, C.; Ji, R.; Ren, X.; Guo, F.; Sun, S.; Shi, J.; Zhang, H.; Zhang, Z.; Wang, L.; Zhang, Y. The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging. J. Control. Release, 2015, 220(Pt A), 545-555.
Deng, H.; Zhong, Y.; Du, M.; Liu, Q.; Fan, Z.; Dai, F.; Zhang, X. Theranostic self-assembly structure of gold nanoparticles for NIR photothermal therapy and X-Ray computed tomography imaging. Theranostics, 2014, 4(9), 904-918.
Qin, J.; Peng, Z.; Li, B.; Ye, K.; Zhang, Y.; Yuan, F.; Yang, X.; Huang, L.; Hu, J.; Lu, X. Gold nanorods as a theranostic platform for in vitro and in vivo imaging and photothermal therapy of inflammatory macrophages. Nanoscale, 2015, 7(33), 13991-14001.
Guo, W.; Guo, C.S.; Zheng, N.N.; Sun, T.D.; Liu, S.Q. CsxWO3 nanorods coated with polyelectrolyte multilayers as a multifunctional nanomaterial for bimodal imaging-guided photothermal/photodynamic cancer treatment. Adv. Mater., 2017.
[ adma.201604157]
Fujimoto, J.G.; Pitris, C.; Boppart, S.A.; Brezinski, M.E. Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia, 2000, 2(1-2), 9-25.
Schmitt, J.M. Optical coherence tomography (OCT): a review. IEEE J. Sel. Top. Quant., 1999, 5(4), 1205-1215.
Kim, S.; Rinehart, M.T.; Park, H.; Zhu, Y.; Wax, A. Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation. Biomed. Opt. Express, 2012, 3(10), 2579-2586.
Liu, Z.; Ye, B.; Jin, M.; Chen, H.; Zhong, H.; Wang, X.; Guo, Z. Dye-free near-infrared surface-enhanced Raman scattering nanoprobes for bioimaging and high-performance photothermal cancer therapy. Nanoscale, 2015, 7(15), 6754-6761.
Jung, S.; Nam, J.; Hwang, S.; Park, J.; Hur, J. Im, K.; Park, N.; Kim, S. Theragnostic pH-sensitive gold nanoparticles for the selective surface enhanced Raman scattering and photothermal cancer therapy. Anal. Chem., 2013, 85(16), 7674-7681.
Gao, Y.; Li, Y.; Wang, Y.; Chen, Y.; Gu, J.; Zhao, W.; Ding, J.; Shi, J. Controlled synthesis of multilayered gold nanoshells for enhanced photothermal therapy and SERS detection. Small, 2015, 11(1), 77-83.
Zeng, L.; Pan, Y.; Wang, S.; Wang, X.; Zhao, X.; Ren, W.; Lu, G.; Wu, A. Raman reporter-coupled Ag-core@Au-shell nanostars for in vivo improved surface enhanced raman scattering imaging and near-infrared-triggered photothermal therapy in breast cancers. ACS Appl. Mater. Interfaces, 2015, 7(30), 16781-16791.
Wang, S.H.; Wei, C.W.; Jee, S.H.; Li, P.C. Quantitative thermal imaging for plasmonic photothermal therapy. J. Med. Biol. Eng., 2011, 31(6), 387-393.
Song, G.S.; Wang, Q.A.; Wang, Y.; Lv, G.; Li, C.; Zou, R.J.; Chen, Z.G.; Qin, Z.Y.; Huo, K.K.; Hu, R.G.; Hu, J.Q. A low-toxic multifunctional nanoplatform based on Cu9S5@mSiO2 core-shell nanocomposites: combining photothermal- and chemotherapies with infrared thermal imaging for cancer treatment. Adv. Funct. Mater., 2013, 23(35), 4281-4292.
Deng, K.R.; Hou, Z.Y.; Deng, X.R.; Yang, P.P.; Li, C.X.; Lin, J. Enhanced antitumor efficacy by 808 nm laser-induced synergistic photothermal and photodynamic therapy based on a indocyanine-green-attached W18O49 nanostructure. Adv. Funct. Mater., 2015, 25(47), 7280-7290.
Zhou, M.; Li, J.; Liang, S.; Sood, A.K.; Liang, D.; Li, C. CuS nanodots with ultrahigh efficient renal clearance for positron emission tomography imaging and image-guided photothermal therapy. ACS Nano, 2015, 9(7), 7085-7096.
Sun, X.; Huang, X.; Yan, X.; Wang, Y.; Guo, J.; Jacobson, O.; Liu, D.; Szajek, L.P.; Zhu, W.; Niu, G.; Kiesewetter, D.O.; Sun, S.; Chen, X. Chelator-free (64)Cu-integrated gold nanomaterials for positron emission tomography imaging guided photothermal cancer therapy. ACS Nano, 2014, 8(8), 8438-8446.
Hong, H.; Chen, F.; Goel, S.; Valdovinos, H.F.; Barnhart, T.E.; Cai, W. Dual-modality positron emission tomography/optical image-guided photodynamic cancer therapy with chlorin e6-containing nanomicelles. ACS Nano, 2016, 10(8), 7721-7730.
Cheng, L.; Kamkaew, A.; Sun, H.; Jiang, D.; Valdovinos, H.F.; Gong, H.; England, C.G.; Goel, S.; Barnhart, T.E.; Cai, W. Dual-modality positron emission tomography/optical image-guided photodynamic cancer therapy with chlorin e6-containing nanomicelles. ACS Nano, 2016, 10(8), 7721-7730.
Pang, B.; Zhao, Y.; Luehmann, H.; Yang, X.; Detering, L.; You, M.; Zhang, C.; Zhang, L.; Li, Z.Y.; Ren, Q.; Liu, Y.; Xia, Y. Cu-64-doped PdCu@Au tripods: a multifunctional nanomaterial for positron emission tomography and image-guided photothermal cancer treatment. ACS Nano, 2016, 10(3), 3121-3131.
Wu, D.; Huang, L.; Jiang, M.S.; Jiang, H. Contrast agents for photoacoustic and thermoacoustic imaging: a review. Int. J. Mol. Sci., 2014, 15(12), 23616-23639.
Yeager, D.; Chen, Y.S.; Litovsky, S.; Emelianov, S. Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study. Theranostics, 2013, 4(1), 36-46.
Lu, W.; Melancon, M.P.; Xiong, C.; Huang, Q.; Elliott, A.; Song, S.; Zhang, R.; Flores, L.G., II; Gelovani, J.G.; Wang, L.V.; Ku, G.; Stafford, R.J.; Li, C. Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res., 2011, 71(19), 6116-6121.
Liang, S.; Li, C.; Zhang, C.; Chen, Y.; Xu, L.; Bao, C.; Wang, X.; Liu, G.; Zhang, F.; Cui, D. CD44v6 monoclonal antibody-conjugated gold nanostars for targeted photoacoustic imaging and plasmonic photothermal therapy of gastric cancer stem-like cells. Theranostics, 2015, 5(9), 970-984.
Huang, P.; Lin, J.; Li, W.; Rong, P.; Wang, Z.; Wang, S.; Wang, X.; Sun, X.; Aronova, M.; Niu, G.; Leapman, R.D.; Nie, Z.; Chen, X. Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. Angew. Chem. Int. Ed. Engl., 2013, 52(52), 13958-13964.
Miao, Q.; Pu, K. Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjug. Chem., 2016, 27(12), 2808-2823.
Han, J.; Zhang, J.; Yang, M.; Cui, D.; de la Fuente, J.M. Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy. Nanoscale, 2016, 8(1), 492-499.
Wang, Y.W.; Fu, Y.Y.; Peng, Q.L.; Guo, S.S.; Liu, G.; Li, J.; Yang, H.H.; Chen, G.N. Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging. J. Mater. Chem. B Mater. Biol. Med., 2013, 1(42), 5762-5767.
Sheng, Z.; Song, L.; Zheng, J.; Hu, D.; He, M.; Zheng, M.; Gao, G.; Gong, P.; Zhang, P.; Ma, Y.; Cai, L. Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. Biomaterials, 2013, 34(21), 5236-5243.
Moon, H.; Kumar, D.; Kim, H.; Sim, C.; Chang, J.H.; Kim, J.M.; Kim, H.; Lim, D.K. Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging. ACS Nano, 2015, 9(3), 2711-2719.
Chen, D.Q.; Wang, C.; Nie, X.; Li, S.M.; Li, R.M.; Guan, M.R.; Liu, Z.; Chen, C.Y.; Wang, C.R.; Shu, C.Y.; Wan, L.J. Photoacoustic imaging guided near-infrared photothermal therapy using highly water-dispersible single-walled carbon nanohorns as theranostic agents. Adv. Funct. Mater., 2014, 24(42), 6621-6628.
Zha, Z.; Zhang, S.; Deng, Z.; Li, Y.; Li, C.; Dai, Z. Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy. Chem. Commun., 2013, 49(33), 3455-3457.
Qian, X.; Shen, S.; Liu, T.; Cheng, L.; Liu, Z. Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy. Nanoscale, 2015, 7(14), 6380-6387.
Zhu, H.; Fang, Y.; Zhen, X.; Wei, N.; Gao, Y.; Luo, K.Q.; Xu, C.; Duan, H.; Ding, D.; Chen, P.; Pu, K. Multilayered semiconducting polymer nanoparticles with enhanced NIR fluorescence for molecular imaging in cells, zebrafish and mice. Chem. Sci., 2016, 7(8), 5118-5125.
Mou, J.; Li, P.; Liu, C.; Xu, H.; Song, L.; Wang, J.; Zhang, K.; Chen, Y.; Shi, J.; Chen, H. Ultrasmall Cu2-xS nanodots for highly efficient photoacoustic imaging-guided photothermal therapy. Small, 2015, 11(19), 2275-2283.
Li, W.; Rong, P.; Yang, K.; Huang, P.; Sun, K.; Chen, X. Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy. Biomaterials, 2015, 45, 18-26.
Bao, T.; Yin, W.; Zheng, X.; Zhang, X.; Yu, J.; Dong, X.; Yong, Y.; Gao, F.; Yan, L.; Gu, Z.; Zhao, Y. One-pot synthesis of PEGylated plasmonic MoO(3-x) hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer. Biomaterials, 2016, 76, 11-24.
Guha, S.; Shaw, G.K.; Mitcham, T.M.; Bouchard, R.R.; Smith, B.D. Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH. Chem. Commun., 2016, 52(1), 120-123.
Gao, S.; Zhang, L.; Wang, G.; Yang, K.; Chen, M.; Tian, R.; Ma, Q.; Zhu, L. Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy. Biomaterials, 2016, 79, 36-45.
Zhang, J.; Zhen, X.; Upputuri, P.K.; Pramanik, M.; Chen, P.; Pu, K. Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite. Adv. Mater., 2017, 29(6), 1604764.
Zhu, C.; Yang, Y.; Luo, M.; Yang, C.; Wu, J.; Chen, L.; Liu, G.; Wen, T.; Zhu, J.; Xia, H. Stabilizing two classical antiaromatic frameworks: demonstration of photoacoustic imaging and the photothermal effect in metalla-aromatics. Angew. Chem. Int. Ed. Engl., 2015, 54(21), 6181-6185.
Wang, X.; Pang, Y.; Ku, G.; Xie, X.; Stoica, G.; Wang, L.V. Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain. Nat. Biotechnol., 2003, 21(7), 803-806.
Zhang, H.F.; Maslov, K.; Stoica, G.; Wang, L.V. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat. Biotechnol., 2006, 24(7), 848-851.
Ntziachristos, V.; Ripoll, J.; Wang, L.V.; Weissleder, R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat. Biotechnol., 2005, 23(3), 313-320.
Wang, L.V.; Hu, S. Photoacoustic tomography: in vivo imaging from organelles to organs. Science, 2012, 335(6075), 1458-1462.
Zackrisson, S.; van de Ven, S.M.W.Y.; Gambhir, S.S. Light in and sound out: emerging translational strategies for photoacoustic imaging. Cancer Res., 2014, 74(4), 979-1004.
Ntziachristos, V.; Razansky, D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chem. Rev., 2010, 110(5), 2783-2794.
Mahmoudi, M.; Serpooshan, V.; Laurent, S. Engineered nanoparticles for biomolecular imaging. Nanoscale, 2011, 3(8), 3007-3026.
Yao, G.; Wang, L.V. Theoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue. Appl. Opt., 2000, 39(4), 659-664.
Wang, Y.W.; Xie, X.Y.; Wang, X.D.; Ku, G.; Gill, K.L.; O’Neal, D.P.; Stoica, G.; Wang, L.V. Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain. Nano Lett., 2004, 4(9), 1689-1692.
Rosencwaig, A.; Gersho, A. Theory of photoacoustic effect with solids. J. Appl. Phys., 1976, 47(1), 64-69.
Chen, Q.; Wen, J.; Li, H.; Xu, Y.; Liu, F.; Sun, S. Recent advances in different modal imaging-guided photothermal therapy. Biomaterials, 2016, 106, 144-166.
Ma, Y.; Huang, J.; Song, S.; Chen, H.; Zhang, Z. Cancer-targeted nanotheranostics: recent advances and perspectives. Small, 2016, 12(36), 4936-4954.
Wang, S.; Lin, J.; Wang, T.; Chen, X.; Huang, P. Recent advances in photoacoustic imaging for deep-tissue biomedical applications. Theranostics, 2016, 6(13), 2394-2413.
Li, W.; Chen, X. Gold nanoparticles for photoacoustic imaging. Nanomedicine, 2015, 10(2), 299-320.
Mallidi, S.; Luke, G.P.; Emelianov, S. Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. Trends Biotechnol., 2011, 29(5), 213-221.
Hu, D.; Liu, C.; Song, L.; Cui, H.; Gao, G.; Liu, P.; Sheng, Z.; Cai, L. Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy. Nanoscale, 2016, 8(39), 17150-17158.
Hu, D.; Zhang, J.; Gao, G.; Sheng, Z.; Cui, H.; Cai, L. Indocyanine green-loaded polydopamine-reduced graphene oxide nanocomposites with amplifying photoacoustic and photothermal effects for cancer theranostics. Theranostics, 2016, 6(7), 1043-1052.
Sheng, Z.; Hu, D.; Zheng, M.; Zhao, P.; Liu, H.; Gao, D.; Gong, P.; Gao, G.; Zhang, P.; Ma, Y.; Cai, L. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy. ACS Nano, 2014, 8(12), 12310-12322.
Guo, M.; Mao, H.; Li, Y.; Zhu, A.; He, H.; Yang, H.; Wang, Y.; Tian, X.; Ge, C.; Peng, Q.; Wang, X.; Yang, X.; Chen, X.; Liu, G.; Chen, H. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials, 2014, 35(16), 4656-4666.
Liu, X.; Yang, G.; Zhang, L.; Liu, Z.; Cheng, Z.; Zhu, X. Photosensitizer cross-linked nano-micelle platform for multimodal imaging guided synergistic photothermal/photodynamic therapy. Nanoscale, 2016, 8(33), 15323-15339.
Yang, Y.; Liu, J.; Liang, C.; Feng, L.; Fu, T.; Dong, Z.; Chao, Y.; Li, Y.; Lu, G.; Chen, M.; Liu, Z. Nanoscale metal-organic particles with rapid clearance for magnetic resonance imaging-guided photothermal therapy. ACS Nano, 2016, 10(2), 2774-2781.
Shi, S.; Liu, Y.; Chen, Y.; Zhang, Z.; Ding, Y.; Wu, Z.; Yin, J.; Nie, L. Versatile pH-response micelles with high cell-penetrating helical diblock copolymers for photoacoustic imaging guided synergistic chemo-photothermal therapy. Theranostics, 2016, 6(12), 2170-2182.
Huang, P.; Rong, P.; Jin, A.; Yan, X.; Zhang, M.G.; Lin, J.; Hu, H.; Wang, Z.; Yue, X.; Li, W.; Niu, G.; Zeng, W.; Wang, W.; Zhou, K.; Chen, X. Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy. Adv. Mater., 2014, 26(37), 6401-6408.
Wang, J.; Zhu, G.; You, M.; Song, E.; Shukoor, M.I.; Zhang, K.; Altman, M.B.; Chen, Y.; Zhu, Z.; Huang, C.Z.; Tan, W. Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy. ACS Nano, 2012, 6(6), 5070-5077.
Jang, B.; Park, J.Y.; Tung, C.H.; Kim, I.H.; Choi, Y. Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo. ACS Nano, 2011, 5(2), 1086-1094.
Chen, N.T.; Tang, K.C.; Chung, M.F.; Cheng, S.H.; Huang, C.M.; Chu, C.H.; Chou, P.T.; Souris, J.S.; Chen, C.T.; Mou, C.Y.; Lo, L.W. Enhanced plasmonic resonance energy transfer in mesoporous silica-encased gold nanorod for two-photon-activated photodynamic therapy. Theranostics, 2014, 4(8), 798-807.
Choi, W.I.; Sahu, A.; Kim, Y.H.; Tae, G. Photothermal cancer therapy and imaging based on gold nanorods. Ann. Biomed. Eng., 2012, 40(2), 534-546.
Kuo, W.S.; Chang, C.N.; Chang, Y.T.; Yang, M.H.; Chien, Y.H.; Chen, S.J.; Yeh, C.S. Gold nanorods in photodynamic therapy, as hyperthermia agents, and in near-infrared optical imaging. Angew. Chem. Int. Ed. Engl., 2010, 49(15), 2711-2715.
Rong, P.; Huang, P.; Liu, Z.; Lin, J.; Jin, A.; Ma, Y.; Niu, G.; Yu, L.; Zeng, W.; Wang, W.; Chen, X. Protein-based photothermal theranostics for imaging-guided cancer therapy. Nanoscale, 2015, 7(39), 16330-16336.
Chen, Q.; Liu, X.; Zeng, J.; Cheng, Z.; Liu, Z. Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors. Biomaterials, 2016, 98, 23-30.
Guha, S.; Shaw, G.K.; Mitcham, T.M.; Bouchard, R.R.; Smith, B.D. Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH. Chem. Commun., 2016, 52(1), 120-123.
Lucky, S.S.; Soo, K.C.; Zhang, Y. Nanoparticles in photodynamic therapy. Chem. Rev., 2015, 115(4), 1990-2042.
Dolmans, D.E.; Fukumura, D.; Jain, R.K. Photodynamic therapy for cancer. Nat. Rev. Cancer, 2003, 3(5), 380-387.
Zheng, X.; Xing, D.; Zhou, F.; Wu, B.; Chen, W.R. Indocyanine green-containing nanostructure as near infrared dual-functional targeting probes for optical imaging and photothermal therapy. Mol. Pharm., 2011, 8(2), 447-456.
Zheng, X.; Zhou, F.; Wu, B.; Chen, W.R.; Xing, D. Enhanced tumor treatment using biofunctional indocyanine green-containing nanostructure by intratumoral or intravenous injection. Mol. Pharm., 2012, 9(3), 514-522.
Park, S.Y.; Baik, H.J.; Oh, Y.T.; Oh, K.T.; Youn, Y.S.; Lee, E.S. A smart polysaccharide/drug conjugate for photodynamic therapy. Angew. Chem. Int. Ed. Engl., 2011, 50(7), 1644-1647.
Wang, S.; Huang, P.; Nie, L.; Xing, R.; Liu, D.; Wang, Z.; Lin, J.; Chen, S.; Niu, G.; Lu, G.; Chen, X. Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars. Adv. Mater., 2013, 25(22), 3055-3061.
Chen, C.; Song, Z.; Zheng, X.; He, Z.; Liu, B.; Huang, X.; Kong, D.; Ding, D.; Tang, B.Z. AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel. Chem. Sci., 2017, 8(3), 2191-2198.
Wang, Y.; Xie, Y.; Li, J.; Peng, Z.H.; Sheinin, Y.; Zhou, J.; Oupický, D. Tumor-penetrating nanoparticles for enhanced anticancer activity of combined photodynamic and hypoxia-activated therapy. ACS Nano, 2017, 11(2), 2227-2238.
Wang, Y.M.; Liu, W.; Yin, X.B. Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy. Chem. Sci., 2017, 8(5), 3891-3897.
Li, W.; Zheng, C.; Pan, Z.; Chen, C.; Hu, D.; Gao, G.; Kang, S.; Cui, H.; Gong, P.; Cai, L. Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy. Biomaterials, 2016, 101, 10-19.
Sheng, Z.; Hu, D.; Zheng, M.; Zhao, P.; Liu, H.; Gao, D.; Gong, P.; Gao, G.; Zhang, P.; Ma, Y.; Cai, L. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy. ACS Nano, 2014, 8(12), 12310-12322.
Lyu, Y.; Xie, C.; Chechetka, S.A.; Miyako, E.; Pu, K. Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons. J. Am. Chem. Soc., 2016, 138(29), 9049-9052.
Pu, K.; Chattopadhyay, N.; Rao, J. Recent advances of semiconducting polymer nanoparticles in in vivo molecular imaging. J. Control. Release, 2016, 240, 312-322.
Zhen, X.; Zhang, C.; Xie, C.; Miao, Q.; Lim, K.L.; Pu, K. Intraparticle energy level alignment of semiconducting polymer nanoparticles to amplify chemiluminescence for ultrasensitive in vivo imaging of reactive oxygen species. ACS Nano, 2016, 10(6), 6400-6409.
Pu, K.; Shuhendler, A.J.; Jokerst, J.V.; Mei, J.; Gambhir, S.S.; Bao, Z.; Rao, J. Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice. Nat. Nanotechnol., 2014, 9(3), 233-239.
Pu, K.; Shuhendler, A.J.; Rao, J. Semiconducting polymer nanoprobe for in vivo imaging of reactive oxygen and nitrogen species. Angew. Chem. Int. Ed. Engl., 2013, 52(39), 10325-10329.
Shuhendler, A.J.; Pu, K.; Cui, L.; Uetrecht, J.P.; Rao, J. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nat. Biotechnol., 2014, 32(4), 373-380.
Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P.G.; Burnham, D.R.; McNeill, J.D.; Chiu, D.T. Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting. J. Am. Chem. Soc., 2010, 132(43), 15410-15417.
Wu, C.; Jin, Y.; Schneider, T.; Burnham, D.R.; Smith, P.B.; Chiu, D.T. Ultrabright and bioorthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry. Angew. Chem. Int. Ed. Engl., 2010, 49(49), 9436-9440.
Howes, P.; Green, M.; Levitt, J.; Suhling, K.; Hughes, M. Phospholipid encapsulated semiconducting polymer nanoparticles: their use in cell imaging and protein attachment. J. Am. Chem. Soc., 2010, 132(11), 3989-3996.
Pu, K.; Shuhendler, A.J.; Valta, M.P.; Cui, L.; Saar, M.; Peehl, D.M.; Rao, J. Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking. Adv. Healthc. Mater., 2014, 3(8), 1292-1298.
Wu, C.; Hansen, S.J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D.R.; McNeill, J.D.; Olson, J.M.; Chiu, D.T. Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting. Angew. Chem. Int. Ed. Engl., 2011, 50(15), 3430-3434.
Li, K.; Ding, D.; Huo, D.; Pu, K.; Ngo, N.P.T.; Hu, Y.; Li, Z.; Liu, B. Conjugated polymer based nanoparticles as dual-modal probes for targeted in vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater., 2012, 22(15), 3107-3115.
Cui, D.; Xie, C.; Lyu, Y.; Zhen, X.; Pu, K. Near-infrared absorbing amphiphilic semiconducting polymers for photoacoustic imaging. J. Mater. Chem. B, 2017, 5(23), 4406-4409.
Yin, C.; Zhen, X.; Zhao, H.; Tang, Y.; Ji, Y.; Lyu, Y.; Fan, Q.; Huang, W.; Pu, K. Amphiphilic semiconducting oligomer for near-Infrared photoacoustic and fluorescence imaging. ACS Appl. Mater. Interfaces, 2017, 9(14), 12332-12339.
Zhen, X.; Feng, X.; Xie, C.; Zheng, Y.; Pu, K. Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging. Biomaterials, 2017, 127, 97-106.
Hong, G.; Zou, Y.; Antaris, A.L.; Diao, S.; Wu, D.; Cheng, K.; Zhang, X.; Chen, C.; Liu, B.; He, Y.; Wu, J.Z.; Yuan, J.; Zhang, B.; Tao, Z.; Fukunaga, C.; Dai, H. Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window. Nat. Commun., 2014, 5, 4206.
Xie, C.; Zhen, X.; Lei, Q.L.; Ni, R.; Pu, K. Self-assembly of semiconducting polymer amphiphiles for in vivo photoacoustic imaging. Adv. Funct. Mater., 2017, 27, 1605397.
Lyu, Y.; Zhen, X.; Miao, Y.; Pu, K. Reactivity-based semiconducting polymer nanoprobes for photoacoustic imaging of protein sulfenic acids. ACS Nano, 2017, 11(1), 358-367.
Xie, C.; Upputuri, P.K.; Zhen, X.; Pramanik, M.; Pu, K. Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging. Biomaterials, 2017, 119, 1-8.
Miao, Q.; Lyu, Y.; Ding, D.; Pu, K. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Adv. Mater., 2016, 28(19), 3662-3668.
Pu, K.; Mei, J.; Jokerst, J.V.; Hong, G.; Antaris, A.L.
Chattopadhyay, N.; Shuhendler, A.J.; Kurosawa, T.; Zhou, Y.; Gambhir, S.S.; Bao, Z.; Rao, J. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo photoacoustic imaging. Adv. Mater., 2015, 27(35), 5184-5190.
Lyu, Y.; Pu, K. Recent advances of activatable molecular probes based on semiconducting polymer nanoparticles in sensing and imaging. Adv. Sci., 2017, 4(6), 1600481.
Yin, C.; Zhen, X.; Fan, Q.; Huang, W.; Pu, K. Degradable semiconducting oligomer amphiphile for ratiometric photoacoustic imaging of hypochlorite. ACS Nano, 2017, 11(4), 4174-4182.
Liang, X.L.; Li, Y.Y.; Li, X.D.; Jing, L.J.; Deng, Z.J.; Yue, X.L.; Li, C.H.; Dai, Z.F. PEGylated polypyrrole nanoparticles conjugating gadolinium chelates for dual-modal MRI/photoacoustic imaging guided photothermal therapy of cancer. Adv. Funct. Mater., 2015, 25, 1451-1462.
Wang, J.; Guo, F.; Yu, M.; Liu, L.; Tan, F.; Yan, R.; Li, N. Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy. J. Control. Release, 2016, 237, 23-34.
Lyu, Y.; Fang, Y.; Miao, Q.; Zhen, X.; Ding, D.; Pu, K. Intraparticle molecular orbital engineering of semiconducting polymer nanoparticles as amplified theranostics for in vivo photoacoustic imaging and photothermal therapy. ACS Nano, 2016, 10(4), 4472-4481.
Zhang, D.; Wu, M.; Zeng, Y.Y.; Liao, L.S.; Cai, Z.X.; Liu, G.; Liu, X.L.; Liu, J.F. Lipid micelles packaged with semiconducting polymer dots as simultaneous MRI/photoacoustic imaging and photodynamic/photothermal dual-modal therapeutic agents for liver cancer. J. Mater. Chem. B Mater. Biol. Med., 2016, 4, 589-599.
Cai, Y.; Liang, P.; Tang, Q.; Yang, X.; Si, W.; Huang, W.; Zhang, Q.; Dong, X. Diketopyrrolopyrrole-triphenylamine organic nanoparticles as multifunctional reagents for photoacoustic imaging-guided photodynamic/photothermal synergistic tumor therapy. ACS Nano, 2017, 11(1), 1054-1063.

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Year: 2019
Page: [1389 - 1405]
Pages: 17
DOI: 10.2174/0929867324666170921103152
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