This review describes the chemistry of 1,2,5- and 1,4,5-thiadiazepines. The investigated
heterocycles are monocyclic and fused 1,2,5- and 1,4,5-thiadiazepines. The different
sections cover: structural elucidation "spectroscopy", reactivity of substituents attached
to ring carbon and nitrogen atoms, synthesis of monocyclic and fused heterocycles
incorporated 1,2,5- and 1,4,5-thiadiazepine moiety. Nitrogen and sulfur atoms of thiadiazepine
ring system have the ability to donate the electrons pairs in order to form coordination
bonds forming different complexes. The aim of this review is to discuss the chemistry
of title compounds up till now. The reaction mechanisms are described and discussed,
as well as, the biological applications of the target compounds.
Keywords: 1, 2, 5-Thiadiazepines, 1, 4, 5-thiadiazepines, spectroscopic data, reactivity, synthetic methods, biological importance.
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