Background: Chronic, degenerative diseases are often characterized by inflammation
and aberrant angiogenesis. For these pathologies, including rheumatoid arthritis, cardiovascular
and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy.
Objectives: The validation of novel (chemo)preventive and interceptive approaches, and the use
of new or repurposed agents, alone or in combination with registered drugs, are urgently required.
Results: Phytochemicals (triterpenoids, flavonoids, retinoids) and their derivatives, nonsteroidal
anti-inflammatory drugs (aspirin) as well as biguanides (metformin and phenformin)
originally developed from phytochemical backbones, are multi-target agents showing antiangiogenic
and anti-anti-inflammatory proprieties. Many of them target AMPK and metabolic
pathways such as the mTOR axis. We summarize the beneficial effects of several compounds in
conferring protection and supporting therapy, and as a paradigm, we present data on terpenoids
& biquanides on beer hop xanthohumol and hydroxytryrosol from olive mill waste waters.
Conclusions: These molecules could be employed for combinatorial chemoprevention and interception
approaches or chemoprevention/therapy regimens for cancer and other chronic complex