Background: Two female breast cancer patients developed epiphora after administration
of cyclophosphamide and/or anthracyclines based 2-day chemotherapy regimen. An ophthalmologist
was consulted and no apparent cause was found.
Case Description: Patients were managed by ciprofloxacin eye drops. Chemotherapy induced ocular
complications are not uncommon, but under reported. Although epiphora is a mild reaction, if severe
however, it can interfere with daily activities. Patients having chemotherapy induced ocular toxicity
should go for ophthalmic examination to pick up ocular adverse effects of anticancer drugs and treat
them at an early stage.
Keywords: Cyclophosphamide, anthracyclines, epiphora, chemotherapy, ophthalmic examination, ocular adverse effects.
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