Effects of Evolocumab on Cardiovascular Events

Author(s): Nasser Mikhail* .

Journal Name: Current Cardiology Reviews

Volume 13 , Issue 4 , 2017

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Abstract:

Background: Evolocumab is a potent lipid-lowering drug that decreases plasma levels of lowdensity lipoprotein cholesterol (LDL-C) by 50-60%. FOURIER is a landmark randomized trial involving 27,564 patients with established cardiovascular disease already on statins and plasma LDLC levels > 70 mg/dl.

Objective: The main objective of FOURIER was to examine the effects of evolocumab on cardiovascular events.

Results: After a mean follow-up of 2.2 years, evolocumab significantly decreased the primary endpoint (composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization) by 15% compared to placebo [hazard ratio 0.85 (95% CI, 0.79-0.92)], but no significant effect was found on mortality. The most common adverse effect of evolocumab was mild injection site reaction occurring in 2.1% of patients versus 1.6% of patients receiving placebo.

Conclusion: These results support the use of evolocumab as add-on therapy to statins for high cardiac- risk patients not achieving optimal goals of LDL-C. Longer-term studies are needed to further clarify the efficacy and safety of evolocumab.

Keywords: Evolocumab, PCSK9, cardiovascular events, LDL-C, FOURIER, mortality.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2017
Page: [319 - 324]
Pages: 6
DOI: 10.2174/1573403X13666170918165713
Price: $58

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