Effects of Apelin Peptides on Diabetic Complications

Author(s): Hong Chen, Chengyu Liu, Cheng Cheng, Ling Zheng, Kun Huang*.

Journal Name: Current Protein & Peptide Science

Volume 19 , Issue 2 , 2018

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Abstract:

Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Here we summarize the current knowledge on the role of apelin in the pathogenesis of different diabetic complications. We also propose that similar to insulin resistance or leptin resistance, diabetics may also show apelin resistance. Potential clinical application of apelin and its analogue peptides in treating diabetic complications is discussed.

Keywords: Apelin, adipokine, diabetes, diabetic complications, metabolic disorder, cardiomyopathy.

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Article Details

VOLUME: 19
ISSUE: 2
Year: 2018
Page: [179 - 189]
Pages: 11
DOI: 10.2174/1389203718666170918154728
Price: $58

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