Background: Cuphea glutinosa is a medicinal species extensively distributed in South of
Brazil, being known in the folk medicine as diuretic, anti-inflammatory, laxative and anti-hypertensive.
In the present work, its majority chemical components present in infusions and macerations obtained
from leaves and roots were investigated. The analytical responses were well worked using a UPLC-MS,
whose detection was standardized for flavonoids due to their importance for this genus and the biological
Conclusion: Using a mobile phase composed by acetonitrile:methanol and 0.1% formic acid, eluted by
gradient, and a ionization mode by positive ESI, four flavonoids were identified: quercetin-3-glucoside,
quercetin-3-arabinoside, quercetin-3-glucuronide and isorhamnetin. Another quercetin derivative was
also detected. The extracts were investigated for antifungal activity by broth microdilution method,
whose results indicated activity against Candida parapsilosis, Candida tropicalis, and Trichosporon
asahii. This antimicrobial potential can be attributed to the chemical profile predominant in flavonoids.