Background: Despite availability of variety of antibacterial agents, re-emergance of
pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective
antibacterial agents is the key interest in the medicinal chemistry research.
Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated
for antimicrobial activities.
Results: A number of derivatives showed significant to moderate antimicrobial activities against
Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal
activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the
most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative
Conclusion: Newly identified compounds may serve as lead for future research in order to get the
more powerful antibacterial agents.