Background: Spiro[4.5]decenones are privileged structural motifs occurring in
various biologically active natural and unnatural compounds. Moreover, they are very
important intermediates in organic synthesis. Therefore, the development of novel onepot
protocols for the synthesis of these synthetically challenging spirocyclic compounds
that benefit from simple, inexpensive, and readily available starting materials continues to
be a target of intense interest. In recent years, tremendous efforts have been made toward
the construction of titled compounds form cheap and readily accessible N-arylpropiolamide
derivatives through intramolecular ipso-cyclization strategy.
Objective/Methodology: This review highlights recent advances in this explosive growing
research area from the year 2005 to 2017.
Conclusion: The review is divided into three major sections. The first section focuses exclusively on ipsohalocyclization
approaches. The second section will discuss oxidative radical ipso-cyclizations. The third will
cover catalytic ipso-cyclizations. Mechanistic aspects of the reactions are considered and discussed in detail.