Depression is a common psychiatric disorder that decreases the quality of life and increases
the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention
with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse
is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin
for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence
on a possible relationship between vitamin D deficiency and depression is growing. In this review, the
authors summarized the evidence on the association between vitamin D status and depression in human
observational studies, followed by clinical trials to evaluate the effects of vitamin D supplementation
in treating depression. In conclusion, vitamin D deficiency may be associated with an increased
risk or severity of depression. Supplementation of vitamin D may confer protection for depressed patients.
Keywords: 1, 25-dihydroxyvitamin D, 25-hydroxyvitamin D, depression, mental health, vitamin D.
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