Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation

Author(s): Naglaa A. Abdel Hafez, Huwaida M.E. Hassaneen, Thoraya A. Farghaly*, Sayed M. Riyadh, Heba S.A. Elzahabi.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 7 , 2018

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Abstract:

Objective and Background: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.

Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.

Keywords: Antitumor activity, Bis-spiropyrazoles, 3, 5-diarylidene-piperidones, hydrazonoyl halides, spiropiperidinecarbinols, ultrasound irradiation.

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Article Details

VOLUME: 18
ISSUE: 7
Year: 2018
Page: [631 - 637]
Pages: 7
DOI: 10.2174/1389557517666170912170027
Price: $58

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