Objective and Background: Hydrazonoyl halides were used as precursors for the synthesis
of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound
irradiation. The products were secluded in good yield after short reaction periods.
Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung
cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f
showed promising activity.
Keywords: Antitumor activity, Bis-spiropyrazoles, 3, 5-diarylidene-piperidones, hydrazonoyl halides, spiropiperidinecarbinols,
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