Novel Findings of Anti-cancer Property of Propofol

Author(s): Jiaqiang Wang , Chien-shan Cheng , Yan Lu , Xiaowei Ding , Minmin Zhu , Changhong Miao* , Jiawei Chen* .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 18 , Issue 2 , 2018

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Abstract:

Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.

Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.

Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.

Keywords: Propofol, anesthetic, general anesthesia, neoplasms, anti-cancer, malignance-modulating.

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Article Details

VOLUME: 18
ISSUE: 2
Year: 2018
Page: [156 - 165]
Pages: 10
DOI: 10.2174/1871520617666170912120327
Price: $58

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