Abstract
Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.
Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.
Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.
Keywords: Propofol, anesthetic, general anesthesia, neoplasms, anti-cancer, malignance-modulating.
Anti-Cancer Agents in Medicinal Chemistry
Title:Novel Findings of Anti-cancer Property of Propofol
Volume: 18 Issue: 2
Author(s): Jiaqiang Wang, Chien-shan Cheng, Yan Lu, Xiaowei Ding, Minmin Zhu, Changhong Miao*Jiawei Chen*
Affiliation:
- Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032,China
- Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032,China
Keywords: Propofol, anesthetic, general anesthesia, neoplasms, anti-cancer, malignance-modulating.
Abstract: Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.
Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.
Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.
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Cite this article as:
Wang Jiaqiang , Cheng Chien-shan , Lu Yan , Ding Xiaowei, Zhu Minmin , Miao Changhong *, Chen Jiawei *, Novel Findings of Anti-cancer Property of Propofol, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1871520617666170912120327
DOI https://dx.doi.org/10.2174/1871520617666170912120327 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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