The Development and Validation of the Accurate and Sensitive HPLC Method for Quantification of Mizoribine in Human Plasma and Its Clinical Applications | BenthamScience


The Development and Validation of the Accurate and Sensitive HPLC Method for Quantification of Mizoribine in Human Plasma and Its Clinical Applications

Author(s): Yanyan Wang, Fanlong Bu, Rui Zhang, Guiyan Yuan, Pingli Li, Xuwang Chen, Benjie Wang, Rong Li, Ruichen Guo*.

Journal Name: Current Pharmaceutical Analysis

Volume 14 , Issue 6 , 2018

Abstract:

Background and Objectives: To establish a simple and reproducible High Performance Liquid Chromatography (HPLC) method for the determination of mizoribine in human plasma using glipizide as Internal Standard (IS).

Methods: The mizoribine in plasma was precipitated with 10% perchloric acid and separated on a Phenomenex Luna NH2 (250 mm

Keywords: Mizoribine, HPLC, therapeutic drug monitoring, clinical, application, validation.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2018
Page: [541 - 546]
Pages: 6
DOI: 10.2174/1573412913666170912102907
Price: $95

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