Background: High-pressure chemistry offers the possibility to have faster and cleaner
transformations thus addressing most of the green chemistry principles. Among the devices recently
developed, Q-tube is worth mentioning since it is cheap, easy to handle, safe and highly versatile.
Methods: The most recent and interesting results obtained using such technique are reviewed in this
Results: Examples of the Q-tube assisted reactions in organic synthesis are presented in a critical
manner making where possible, a comparison with conventional heating strategies and unconventional
energy source such as microwave or ultrasounds assisted synthesis. The application of Q-tube pressure
reactor in biofuels manufacture is also discussed.
Conclusion: The literature survey clearly revealed that Q-tube is a valid tool in organic synthesis.