Advances in Organic Synthesis

Advances in Organic Synthesis

Volume: 7

Indexed in: EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...
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Different Concepts of Catalysis in the Synthesis of Xanthenediones: A Brief Overview

Pp. 199-227 (29)

Milene Lopes da Silva, Róbson Ricardo Teixeira and Giovanni Wilson Amarante

Abstract

Xanthenediones, also known as 1,8-dioxo-octahydroxanthenes, are synthetic compounds characterized by the presence of a pyran nucleus fused to two cyclohexen- 2-one rings. They present important biological activities as well as possible technological applications. Typically, xanthenediones are derived from the sequence reaction: Knoevenagel condensation, Michael addition and dehydration. During the cyclization step involved in the preparation of xanthenodiones, the use of a catalyst is required. Within this context, a variety of catalysts has been employed for the synthesis of xanthenediones. It is herein described an overview of catalytic methodologies that have been reported to achieve the preparation of xanthenediones.

Keywords:

1, 8-dioxo-octahydroxanthenes, Brønsted acid, Catalysts, Ionic liquid, Lewis acid, Lewis and Brønsted acid, Nanocatalyst, Organocatalyst, Pharmacological activities, Xanthenediones, Xanthenes.

Affiliation:

Universidade Federal de Viçosa, Av. P. H. Rolfs, s/n, Viçosa, Minas Gerais State, Brazil.