Background: Plant-derived ceramides are functional natural products with various
physiological effects that improve water retention and skin permeability functions.
Objective: Herein, we isolated peach (Prunus persica)-derived glucosylceramide with high
purity and evaluated its effects on moisture and permeability of skin.
Methods: Three separate experiments were performed: evaluations of the effect of peachderived
glucosylceramide application on the ceramide content in a three-dimensional human
cultured skin model, water retention effect of the oral administration of the peach-derived
glucosylceramide on human skin functionality, and safety of the long-term administration of
the peach-derived glucosylceramide in human subjects.
Results: Treatments of three-dimensional cultures of human skin with peach-derived glucosylceramide
led to dose-dependent increases in human ceramide contents. Additionally, after
oral administration of ceramide to humans, dose-dependent improvements in water retention
functions of skin, suppression of trans-epidermal water loss and improvements in skin texture
were observed. Furthermore, no significant changes in subjective/objective symptoms,
physical characteristics, or laboratory test values were observed in human subjects following
long term oral administration of ceramide at doses that were 4.5-9-times greater than recommended.
Taken together, the present data indicate the positive effects of peach ceramide
on skin function and no adverse effects.
Conclusion: Ingestion of peach ceramide safely improved the state of the skin.