Background: Ammonium bifluoride is a reagent widely used in organic synthesis;
however, the systematic collection and classification have not been covered until
Methodology: In this review, we aim to systematically summarize the application of ammonium
bifluoride in organic synthesis.
Conclusion: It can be used for deprotection of hydroxyl protected groups (esp. Silyl protection).
It is also used for introducing F & N atoms into organic molecules; promoting
cyclization reactions acting as a multifunctional reagent.
Keywords: Ammonium bifluoride, removal of hydroxyl protecting groups, fluoride source, nitrogen source, cyclization, multifunction
reagent, organic synthesis.
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