Background: Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs)
within the stromal vascular fraction of subcutaneous adipose tissue. ADSCs secrete growth factors and
other proteins, and have been used to regenerate skin with satisfactory results.
Objective: This review focuses on the effect of ADSCs and their secretory factors on the stimulation of
hair growth in vitro, ex vivo and in vivo.
Results: The conditioned media of ADSCs (ADSC-CM) increases the proliferation rate of human follicular
cells. ADSCs-derived proteins improve hair growth and protect human dermal papilla cells
against cytotoxic injury caused by androgen and reactive oxygen species. Moreover, ADSC-CM induces
the anagen phase and promotes hair growth in mice, and enhances the elongation of hair shafts in
ex vivo human hair organ cultures.
Conclusion: ADSC-CM promotes hair growth in vitro, ex vivo, and in vivo. Given that ADSCs are one
of the most accessible sources of MSCs, ADSC-derived proteins may be feasible clinical therapeutic
agents for the treatment of hair loss.