Background: Stable angina is a debilitating and progressive disease caused by narrowing of the coronary
arteries, which in turn affects cardiac perfusion. Statins have a well-established role, modifying symptoms
and progression of the disease not only through lipid lowering, but also through pleiotropic effects.
Objective: We sought to evaluate the effect of statins in stable angina pectoris
Method: We performed a systematic review of the literature searching MEDLINE via Pubmed for all studies
which examine the possible effects of statins in stable angina pectoris.
Results: Statins have demonstrated favourable modification of both biochemical markers (oxidative stress, inflammatory
and coagulation markers/factors) and clinical symptoms (anginal and ischemic) of the disease. These
effects have been demonstrated in vitro, ex vivo and in vivo in animals and humans, independently of the lipid
Conclusion: With an excellent safety profile and evidence of efficacy in managing patients with stable angina,
statins appear an essential part of the therapeutic armoury against atherosclerotic disease.