Abstract
Background: Xanthenes are a class natural and synthetic heterocyclic compounds that exhibit a broad spectrum of biological and synthetic applications. The readership of this review paper will consist of chemists involved with organic chemistry, synthetic organic chemists, pharmacists and biochemists.
Objective: This review aims to present an overview of the chemical aspects of low molecular weight xanthenes and their chemical synthesis by cycloaddition in the search for bioactive species, new catalysts and other applications.
Method: We have comprehensively and critically discussed all the information available in the literature concerning the synthesis and reactivity of this molecules.
Results: This manuscript presents an overview about the chemical aspects of low molecular weight xanthenes and its chemical synthesis by cycloaddition in the search for bioactive species, new catalyst and other applications.
Conclusion: In summary, xanthenes are a class very explored because the broad spectrum of biological properties as previously mentioned. Due this fact, synthetic strategies for obtain this system have been explored with general success with two or three component, and for instance, with benzyne intermediates. It's possible react a 1,3-dicarbobyl compound such as lawsone, dimedone, Meldrum acid, coumarin, phenols and naphthols with different aldehydes.
Keywords: Quinone, lawsone, heterocycles, phenol, naphthol, dimedone, Meldrum' acid, coumarin.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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