Background: The synthesis of new hybrid molecules consisting of several heterocyclic
pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried
out by conventional and successfully optimized microwave mediated techniques.
Methods: The structures of new compounds were confirmed using spectroscopic techniques. These
compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis,
S. aureus, E. faecalis, B. cereus and M. smegmatis.
Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on
the test microorganisms when compared with ampicillin with the mic values varying between 0.03-
Keywords: Fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole, piperazine, antibacterial activity, antioxidant activity,
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