Background: Microwave irradiation has emerged as a useful synthetic strategy
for chemists and drug developers due to enhanced yields, regioselectivity, and faster reaction
times. One area of importance in its practice has been the design of spiro compounds,
which possess great interest on account of their natural occurrence and medicinal capabilities.
The increasingly large number of these scaffolds and unlimited amount of methodologies
utilized in their preparation have made them good candidates for the microwave
Conclusion: Therefore, this review emphasizes the use of microwave irradiation in the
synthesis of spiro heterocyclic compounds.