Gels in Biomedical Applications: An Overview on Wound Healing and Tissue Engineering
Pp. 323-353 (31)
M. Fernanda Horst and Mariela Agotegaray
Biopolymer hydrogels present diverse applications in medicine due to their
biocompatibility, biodegradability and low immunogenicity. The specific features
related to swelling, holding a large amount of water while maintaining the structure, in
addition to the ease of taking different shapes, make them the selected biomaterials as
component for diverse bio-applications: contact lenses, injectable or implantable drug
delivery devices and as platforms intended for wound healing and tissue engineering.
In general, the restriction associated to the use of hydrogels in biomedicine lies in the
poor mechanical properties associated to the natural biopolymers. This problem can be
solved by the use of other materials during the synthesis procedure. In this chapter,
general synthesis methodologies and latest innovations in terms of gelatin, collagen and
hyaluronic acid hydrogels for wound care and tissue engineering are reviewed. The
selection of the biopolymers is based on their suitable features for biomedical
applications. The focusing of specific clinical challenges for wound healing and tissue
engineering can prove to be beneficial for rapid development in science and marketing.
This implies considering the current increasing market associated to hydrogel
employment for wound care and treatment as well as the requirement to develop
concise clinical hydrogels implementation on the replacement of diverse tissue and
Biopolymers, Collagen, Gelatin, Gels, Hyaluronic acid, Synthesis and
characterization, Tissue Engineering, Wound healing.
South Institute of Chemistry (INQUISUR), National Council of Scientific and Technical Research (CONICET), National University of South (UNS), Bahía Blanca, Buenos Aires, Argentina.