Background: All stages of chronic kidney disease (CKD) are associated with increased risks of atherosclerosis
and cardiovascular morbidity and mortality. According to studies, levels of copeptin, growth differentiation
factor-15 (GDF-15) and heart fatty-acid binding protein (h-FABP) are increased in dialysis patients.
Materials: This study included 50 patients (19 women, 31 men) chronically undergoing haemodialysis. The concentration
of markers such as: copeptin, GDF-15, h-FABP, troponin and serum creatine kinase MB (CKMB) was
measured with the use of ELISA tests. Serum concentration of 10 high-density lipoprotein (HDL) subfractions
and 7 low-density lipoprotein (LDL) subfractions was analysed with the use of Lipoprint™ system (Quantimetrix
Results: In this study, we observed higher copeptin level, lower percentage share of cholesterol HDL4 subfraction
and higher percentage share of small HDL particles subfraction in HD patients with diabetes mellitus than in
those without diabetes. We also found significantly lower percentage share of cholesterol HDL5 subfraction in
patients with GDF-15 > 3rd quartile (Q3) compared with those with GFD-15 ≤ Q3. Finally, it was observed that
the percentage share of cholesterol HDL5 subfraction was significantly lower in patients with h-FABP > Q3, and
the share of intermediate HDL subfractions was significantly lower in haemodialysis (HD) patients with h-FABP
> 75 percentile.
Conclusion: The fact that increased level of one biomarker correlated with higher values of other markers may
suggest that their concentration depends on the severity of disease. The obtained results also suggest that the
measurement of copeptin may support the diagnosis of cardiovascular problems in dialysis patients.