Dynamic Biomarkers of Response to Antiangiogenic Therapies in Colorectal Cancer: A Review

(E-pub Ahead of Print)

Author(s): Jesus Rodriguez-Pascual*, Antonio Cubillo.

Journal Name: Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics)

Volume 15 , 2017

Abstract:

Background: Identification of clinical and molecular biomarkers to predict dynamic response or monitor in real-time the efficacy of antiangiogenic therapy represents a major point in the treatment of patients with advanced colorectal cancer. Several studies have been conduced to identify some predictive biomarkers to select patients who will benefit from bevacizumab, the most widely used antiangiogenic monoclonal antibody.

Conclusion: After a decade since the introduction of bevacizumab, no effective predictive biomarkers are available in routine clinical practice. In this review, we summarized the potential candidate dynamic biomarkers that may play a role in this setting.

Keywords: Colorectal cancer, bevacizumab, biomarkers, angiogenesis, chemotherapy, metastatic disease.

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Article Details

VOLUME: 15
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1875692115666170815161754

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