A One-Pot Multicomponent Synthesis of Naphthoxazin-3-one Derivatives Using Amberlite IRA-400 Cl Resin as Green Catalyst

Author(s): Gurusamy Harichandran*, Parkunan Parameswari, Ponnusamy Shanmugam.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 7 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

An efficient Amberlite IRA-400 Cl resin catalyzed, solvent-free, one-pot synthesis of 1- aryl-1,2-dihydro-3H-naphtho[1,2-e][1,3]oxazin-3-ones via three-component reaction of arylaldehydes, urea, and β-naphthol are described. This method offers advantages such as easy work-up, low environmental impact, shortened reaction times, and high yields. The catalyst recovered was reused four times without significant loss of catalytic activity.

Keywords: Amberlite IRA-400 Cl resin, naphthoxazin-3-ones, solvent-free conditions, three-component reaction, green catalyst, therapeutic agents.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 7
Year: 2018
Page: [600 - 605]
Pages: 6
DOI: 10.2174/1570178614666170811151040
Price: $65

Article Metrics

PDF: 12
HTML: 4
EPUB: 1
PRC: 1

Special-new-year-discount