Frontiers in Natural Product Chemistry

Frontiers in Natural Product Chemistry

Volume: 3

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in ...
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The Biological Activities and Synthesis of 2,6- Disubstituted Piperidinols

Pp. 196-220 (25)

Yasunao Hattori and Hidefumi Makabe

Abstract

2,6-Disubstituted piperidinols are one of the most investigated groups of compounds owing to their potential therapeutic use and unique structures. They show a wide variety of biological activities, including inhibition of superoxide anion production, influence on the central nervous system, antibacterial, and plant growth inhibition. For these reasons, 2,6-disubstituted piperidinols have attracted attention from medicinal, phyto-, and synthetic organic chemists. In this review, the biological profile and chemistry of 2,6-disubstituted piperidinols are described. Recent developments in synthetic methods for 2,6-disubstituted piperidinols are also discussed.

Keywords:

2, 6-Disubstituted piperidinols, Antibacterial, Antiparasitic, Bioactive compounds, DNA-damaging, inhibitor, Fucosidase, Nervous system, Synthesis, Plant growth.

Affiliation:

Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kami-ina, Nagano 399-4598, Japan.