A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolyl carbamates

Author(s): Vijaya Durga Thripuram, Hari Babu Bollikolla*, Siva Nagi Reddy Mule, Sailaja Kumari Battula, Vasu Babu Ala.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 7 , 2018

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Abstract:

An efficient and convenient substitution protocol was developed for the synthesis of novel benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethylphosphoramide (HMPA) and t-BuLi medium at -78°C to room temperature. The reactions were monitored with TLC for about 3-4 h. The yields obtained were also considerably good.

Keywords: α-amido sulphones, benzyl (imidazolyl) (aryl) methyl carbamate, Hexamethylphosphoramide, t-BuLi, imidazole, imidazolyl carbamate.

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Article Details

VOLUME: 15
ISSUE: 7
Year: 2018
Page: [569 - 574]
Pages: 6
DOI: 10.2174/1570178614666170811121704
Price: $65

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