An efficient and convenient substitution protocol was developed for the synthesis of novel
benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with
a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethylphosphoramide (HMPA) and
t-BuLi medium at -78°C to room temperature. The reactions were monitored with TLC for about 3-4 h.
The yields obtained were also considerably good.
Keywords: α-amido sulphones, benzyl (imidazolyl) (aryl) methyl carbamate, Hexamethylphosphoramide, t-BuLi, imidazole,
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