Association between Apo B Levels in Mothers and in their Pre-school Age Offspring

Title:Association between Apo B Levels in Mothers and in their Pre-school Age Offspring

Volume: 15 Issue: 1

Author(s): Valeria Hirschler*, Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Walter Tetzlaff and Fernando Brites

Affiliation:

• University of Buenos Aires, Maipu 812, 5M, Buenos Aires (1006),Argentina

Keywords: Cardiovascular disease, dyslipidemia, apo B, pre-school children, mothers, BMI.

Abstract: Objective: The study aims to determine the association between apo B levels in mothers and their pre-school offspring.

Methods: Anthropometric measurement (e.g. BMI), lipids, lipoproteins, and apolipoproteins (e.g. apo B) levels in mothers and their children were obtained in November 2015 in Buenos Aires.

Results: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39.2 % (33) in mothers and 22.6 % (19) in children, and the prevalence of obesity was 38.1% (32) in mothers and 10.7% (9) in children. Multiple linear regression analysis showed that maternal apo B levels were associated with apo B levels in their offspring, adjusted for confounding variables (Beta=0.29; p=0.03; R2=0.25). Furthermore, offspring born to mothers with high apo B levels were six times likelier to have high apo B levels (OR), 5.7; (95% CI 1.3-25.5).

Conclusion: This study suggests that maternal apo B levels were significantly associated with apo B concentration in their pre-school age children.

Cite this article as:

Hirschler Valeria *, Martin Maximiliano, Oestreicher Karen , Molinari Claudia , Boero Laura , Tetzlaff Walter and Brites Fernando , Association between Apo B Levels in Mothers and in their Pre-school Age Offspring, Cardiovascular & Hematological Agents in Medicinal Chemistry 2017; 15 (1) . https://dx.doi.org/10.2174/1871525715666170811112356