Background: Plants offer various novel and structurally diverse potential chemical moieties
which can be used as drugs or as leads for drug discovery. A comprehensive overview of the
genus Diospyros L. (Family: Ebenaceae) is presented.
Methods: A through literature search has been carried out using various search engines and all the
reported data is incorporated followed by discussion of various selected experimental procedures for
extraction, isolation and pharmacological evaluation.
Results: The available data supports importance of Diospyros melanoxylon from its traditional medicinal
value to advance pharmacognostic and pharmacological studies. Extracts and pure compounds
from this genus have been reported for their antimicrobial, anti-inflammatory, cytotoxic, antidiabetic,
antioxidant, antidiarrheal, and antiprotozoal activities. The medicinal uses section is concluded
with details for various isolated chemical constituents.
Conclusion: Presence of proteins and amino acids, tannin and phenolic compound, glycoside, sterol
and steroids is found to be correlated with different pharmacological activities. The narrative review
provide guidelines for the current area of research as well as for future investigations to benefit the
field of medicinal and pharmaceutical sciences.