Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica

Author(s): Reham Al-Harbi, Mona Shaaban*, Razan Al-wegaisi, Fatma Moharram, Ola Abd El-Rahman, Shahenda El-Messery.

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 5 , 2018

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Abstract:

Background: High rate of bacterial infection potentiates scientists to search natural products for new antimicrobial agents.

Methods: This research determines the antimicrobial activity of tannins isolated from Pimenta dioica leaves on Gram-positive and Gram-negative infectious organisms using agar diffusion method.

Results: All tested compounds were effective against Staphylococcus epidermidis, particularly pedunculagin and nilocitin exhibited broad spectrum antibacterial effects against tested isolates as quantified by microtiter plate dilution method.

Conclusion: This will open the era for in-vivo assessment of such compounds for clinical applications.

Keywords: Antimicrobial activity, pedunculagin, nilocitin, molecular docking, Pimenta dioica, tannins.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2018
Page: [508 - 515]
Pages: 8
DOI: 10.2174/1570180814666170810113850
Price: $58

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