Background: High rate of bacterial infection potentiates scientists to search natural
products for new antimicrobial agents.
Methods: This research determines the antimicrobial activity of tannins isolated from Pimenta
dioica leaves on Gram-positive and Gram-negative infectious organisms using agar diffusion
Results: All tested compounds were effective against Staphylococcus epidermidis, particularly
pedunculagin and nilocitin exhibited broad spectrum antibacterial effects against tested isolates as
quantified by microtiter plate dilution method.
Conclusion: This will open the era for in-vivo assessment of such compounds for clinical applications.
Keywords: Antimicrobial activity, pedunculagin, nilocitin, molecular docking, Pimenta dioica, tannins.
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